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INCT 2014: biodiversity and natural products

Grant number: 14/50926-0
Support type:BIOTA-FAPESP Program - Thematic Grants
Duration: July 01, 2017 - June 30, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Cooperation agreement: CNPq - INCTs
Principal Investigator:Vanderlan da Silva Bolzani
Grantee:Vanderlan da Silva Bolzani
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Co-Principal Investigators:Alberto José Cavalheiro ; Leticia Veras Costa Lotufo ; Maria José Soares Mendes Giannini
Associated grant(s):18/50025-3 - Green analytical chemistry applied to the investigation of agro industrial wastes generated in Brazil and Australia, AP.R


The project outlined is focused on the background of Science, Technology & Innovation. The leading core of all scientific societies: (a) excellence in basic and applied research; (b) strong human resources formation in all fields involving biodiversity and natural products; (c) cooperation with the industry sector to accelerate technological innovation development based on natural products; (d) dissemination of knowledge on biodiversity and bioactive natural products for high school and other segments of our society; (e) contribution to support new actions of public policies for the conservation and sustainable use of our biodiversity. TaIking these into account the National Institute of Science & Technology (INCTBioNat) was created to map and catalog in an organized manner all scientific information on the secondary metabolites detected and/or isolated from our rich biodiversity, which is (are?) the keys to the development and advancement of the (research in) Chemistry of Natural Products research in Brazil. The knowledge and sustainable use of the Brazilian biodiversity was encouraged in the document National Biodiversity Policy, edited by the Secretariat of Biodiversity and Forests (SBF). Ministry of the Environment (MMA) in 2002 and has as priority the national economic and social development. The creation of a national network to (for) searching for, and mapping secondary metabolites from terrestrial and marine sources. (species of) and from microorganisms species of our biodiversity, constitutes a rational strategy for selecting the most promising active compounds for further pharmacological and toxicological studies pursuing the discovery of leading (aimed at Iead) molecules. To achieve these goals, the creation of an ICNTBioNat was established in order to bring (for conveying) together experienced seniors (researchers) and talented young researchers, who are beginning their careers in federal and state universities, in several states of the federation, embracing all regions of Brazil. The whole (every) team will work in a collaborative and multidisciplinary approach pursuing the (aimed at) strengthening of this essential and strategic research area for innovation and technological development of Brazil, through a network of natural product laboratories of excellence in natural products) aiming the exploration and sustainable use of the Brazilian rich biodiversity. (AU)

Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUSA, IRAN DA LUZ; XIMENES, VALDECIR FARIAS; DE SOUZA, AGUINALDO ROBINSON; MORGON, NELSON HENRIQUE. Solvent-induced Stokes' shift in DCJTB: Experimental and theoretical results. Journal of Molecular Structure, v. 1192, p. 186-191, SEP 15 2019. Web of Science Citations: 0.
FERREIRA SANTOS, NATACHA CARVALHO; VALLI, MARILIA; BOLZANI, VANDERLAN DA SILVA. A brief overview on Brazilian women in chemistry. Pure and Applied Chemistry, v. 91, n. 4, SI, p. 743-749, APR 2019. Web of Science Citations: 0.
BORGES, MAIARA S.; BIASETTO, CAROLINA R.; CHAPLA, VANESSA M.; EBRAHIMI, SAMAD N.; COSTA, MAYRA F.; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R. Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam. Journal of the Brazilian Chemical Society, v. 30, n. 3, SI, p. 522-527, MAR 2019. Web of Science Citations: 0.
SALDIVAR-GONZALEZ, FERNANDA I.; VALLI, MARILIA; ANDRICOPULO, ADRIANO D.; BOLZANI, VANDERLAN DA SILVA; MEDINA-FRANCO, JOSE L. Chemical Space and Diversity of the NuBBE Database: A Chemoinformatic Characterization. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 59, n. 1, p. 74-85, JAN 2019. Web of Science Citations: 2.
BERTOZO, LUIZA DE CARVALHO; NETO, ERNESTO TAVARES; DE OLIVEIRA, LEANDRO CRISTANTE; XIMENES, VALDECIR FARIAS. Oxidative Alteration of Trp-214 and Lys-199 in Human Serum Albumin Increases Binding Affinity with Phenylbutazone: A Combined Experimental and Computational Investigation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 10 OCT 2018. Web of Science Citations: 0.
SOUZA, FELIPE DE OLIVEIRA; SORBO, JULIANA MARIA; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; ROSA, JOSE CESAR; CZERNYS, ERICA DA SILVA; VALENTE, VALERIA; MOREIRA, THAIS FERNANDA; NAVEGANTE, GEOVANA; FERNANDES, BARBARA COLATTO; SOARES, CHRISTIANE PIENNA. Nitensidine B affects proteins of the glycolytic pathway and induces apoptosis in cervical carcinoma cells immortalized by HPV16. Phytomedicine, v. 48, p. 179-186, SEP 15 2018. Web of Science Citations: 1.
XIMENES, VALDECIR FARIAS; MORGON, NELSON HENRIQUE; DE SOUZA, AGUINALDO ROBINSON. Solvent-dependent inversion of circular dichroism signal in naproxen: An unusual effect!. CHIRALITY, v. 30, n. 9, p. 1049-1053, SEP 2018. Web of Science Citations: 0.
BOBEY, ANTONIO FERNANDEZ; FERREIRA PINTO, MERI EMILI; CILLI, EDUARDO MAFFUD; LOPES, NORBERTO PEPORINE; BOLZANI, VANDERLAN DA SILVA. A Cyclotide Isolated from Noisettia orchidiflora (Violaceae). Planta Medica, v. 84, n. 12-13, SI, p. 947+, AUG 2018. Web of Science Citations: 0.
Coupled monolithic columns as an alternative for the use of viscous ethanol–water mobile phases on chromatographic fingerprinting complex samples. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 3, p. -, Jun. 2018.
FUNARI, CRISTIANO SOLEO; CAVALHEIRO, ALBERTO JOSE; CARNEIRO, RENATO LAJARIM. Coupled monolithic columns as an alternative for the use of viscous ethanol-water mobile phases on chromatographic fingerprinting complex samples. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 3, p. 261-266, MAY-JUN 2018. Web of Science Citations: 0.
RUSSO, HELENA MANNOCHIO; GONCALVES NUNES, WILHAN DONIZETE; BOLZANI, VANDERLAN DA SILVA; IONASHIRO, MASSAO; CAIRES, FLAVIO JUNIOR. Thermoanalytical and spectroscopic characteristics of young and old leaves powder and methanolic extracts of Niedenzuella multiglandulosa. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 132, n. 1, p. 771-776, APR 2018. Web of Science Citations: 1.
WOLF, VANESSA GONCALVES; BONACORSI, CIBELE; GONCALVES RADDI, MARIA STELLA; DA FONSECA, LUIZ MARCOS; XIMENES, VALDECIR FARIAS. Octyl gallate, a food additive with potential beneficial properties to treat Helicobacter pylori infection. FOOD & FUNCTION, v. 8, n. 7, p. 2500-2511, JUL 1 2017. Web of Science Citations: 3.
VENTURINI, DIEGO; DE SOUZA, AGUINALDO ROBINSON; CARACELLI, IGNEZ; MORGON, NELSON HENRIQUE; DA SILVA-FILHO, LUIZ CARLOS; XIMENES, VALDECIR FARIAS. Induction of axial chirality in divanillin by interaction with bovine serum albumin. PLoS One, v. 12, n. 6 JUN 2 2017. Web of Science Citations: 3.
MUSTEDANAGIC, JASMIN; XIMENES, VALDECIR FARIAS; NAGL, MARKUS. Microbicidal activity of N-chlorotaurine in combination with hydrogen peroxide. AMB EXPRESS, v. 7, MAY 23 2017. Web of Science Citations: 1.

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