The study of vascular permeability in the malaria-associated acute respiratory distress syndrome

• Grant number: 17/05782-8
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2017
• End date: December 31, 2019
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Sabrina Epiphanio
• Grantee: Sabrina Epiphanio
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Cláudio Romero Farias Marinho ; João Henrique Ghilardi Lago

Abstract

Malaria, an infectious parasitic disease considered a public health problem, represents a risk to the most diverse populations. Present in 97 endemic countries, this disease puts at risk 40% of the world's population. Plasmodium spp. infections can lead to a severe respiratory condition, with pulmonary complications such as acute respiratory distress syndrome (ARDS). This syndrome is characterized by acute inflammation, alveolar-endothelial and pulmonary parenchymal lesion, dysfunction and increased permeability of the pulmonary alveolar-capillary barrier and consequently edema formation. The regulation mechanisms of endothelial cells permeability involving dynamic interactions and structural alterations of the cytoskeletal components play a critical role in the modulation of the inflammatory response and maintenance of the pulmonary endothelium. Taking into account the lack of knowledge about many of the determinants of the pathogenesis of ARDS associated with malaria, this project aims to identify mechanisms of increased vascular permeability, with emphasis on the study of interendothelial junctions, cytoskeletal changes and their signaling pathways, as well as methods of early diagnosis and therapeutic interventions. The understanding of these aspects is crucial for the development of prophylactic strategies and for the treatment of malaria-associated ARDS. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOMBROWSKI, JAMILLE GREGORIO; BARATEIRO, ANDRE; MACHADO PEIXOTO, ERIKA PAULA; CLAUDIO DA SILVA BARROS, ANDRE BOLER; DE SOUZA, RODRIGO MEDEIROS; CLARK, TAANE GREGORY; CAMPINO, SUSANA; WRENGER, CARSTEN; WUNDERLICH, GERHARD; PALMISANO, GIUSEPPE; et al. Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon. PLoS Neglected Tropical Diseases, v. 15, n. 4, APR 2021. (17/03966-4, 17/03939-7, 18/18257-1, 19/12068-5, 15/26722-8, 17/24267-7, 20/06747-4, 18/20468-0, 20/04923-0, 18/15549-1, 17/05782-8)

REIS, ARAMYS S.; BARBOZA, RENATO; MURILLO, OSCAR; BARATEIRO, ANDRE; PEIXOTO, ERIKA P. M.; LIMA, FLAVIA A.; GOMES, VINICIUS M.; DOMBROWSKI, JAMILLE G.; LEAL, VINICIUS N. C.; ARAUJO, FRANCIELE; et al. Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes. SCIENCE ADVANCES, v. 6, n. 10, MAR 2020. (14/09964-5, 15/23395-6, 14/20451-0, 17/03939-7, 11/19048-8, 17/05782-8, 13/16417-8, 16/07030-0, 12/16525-2, 12/04755-3, 15/50650-7, 18/20468-0, 13/00981-1, 11/17880-8, 15/06106-0)

BARATEIRO, ANDRE; PEREIRA, MARCELO L. M.; EPIPHANIO, SABRINA; MARINHO, CLAUDIO R. F.. Contribution of Murine Models to the Study of Malaria During Pregnancy. FRONTIERS IN MICROBIOLOGY, v. 10, JUN 19 2019. (12/10081-5, 17/05782-8, 17/03939-7, 18/20468-0)

ORTOLAN, LUANA DOS SANTOS; SERCUNDES, MICHELLE KLEIN; MOURA, GABRIEL CANDIDO; QUIRINO, THATYANE DE CASTRO; DEBONE, DANIELA; COSTA, DOUGLAS DE SOUSA; MURILLO, OSCAR; FARIAS MARINHO, CLAUDIO ROMERO; EPIPHANIO, SABRINA. Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2019, DEC 4 2019. (14/20451-0, 13/20718-3, 13/00981-1, 17/05782-8, 17/00077-4)

QUIRINO, THATYANE DE CASTRO; ORTOLAN, LUANA DOS SANTOS; SERCUNDES, MICHELLE KLEIN; FARIAS MARINHO, CLAUDIO ROMERO; TURATO, WALTER MIGUEL; EPIPHANIO, SABRINA. Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis. PLoS One, v. 15, n. 5, MAY 29 2020. (13/20718-3, 17/05782-8)

LIMA, FLAVIA AFONSO; BARATEIRO, ANDRE; DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; COSTA, DOUGLAS DE SOUSA; MURILLO, OSCAR; EPIPHANIO, SABRINA; GONCALVES, LIGIA ANTUNES; FARIAS MARINHO, CLAUDIO ROMERO. Plasmodium falciparum infection dysregulates placental autophagy. PLoS One, v. 14, n. 12, DEC 5 2019. (17/03939-7, 17/05782-8, 13/16417-8, 12/04755-3, 16/07030-0, 15/06106-0, 13/00981-1, 18/20468-0)