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INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach

Grant number: 14/50928-2
Support type:Research Projects - Thematic Grants
Duration: July 01, 2017 - June 30, 2023
Field of knowledge:Health Sciences - Pharmacy
Cooperation agreement: CNPq - INCTs
Principal Investigator:Maria Vitória Lopes Badra Bentley
Grantee:Maria Vitória Lopes Badra Bentley
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated grant(s):17/17455-1 - INCT 2014 - pharmaceutical nanotechnology: a transdisciplinary approach - Proc. n. 2014/50928-2, fluorescence microscope, AP.EMU
17/17456-8 - INCT 2014 - Pharmaceutical nanotechnology: a transdisciplinary approach - Proc. n. 2014/50928-2, ultra-performance liquid chromatograph - UPLC, AP.EMU
17/17075-4 - INCT 2014 - nanotechnology: a transdisciplinary approach - INCT-NANOFARMA - Proc. n. 2014/50928- 2, NanoSight NS300, AP.EMU
+ associated grants 17/17076-0 - INCT 2014 - pharmaceutical nanotechnology: a transdisciplinary approach - Proc. n. 2014/50928-2, vitrocell system, AP.EMU
17/17078-3 - INCT 2014 pharmaceutical nanotechnology - a transdisciplinary approach - Proc. n. 2014/50928-2, atomic force microscope, AP.EMU
17/17079-0 - INCT 2014 - pharmaceutical nanotechnology: a transdisciplinary approach - Proc. n. 2014/50928-2, automatic system for tests in vertical diffusion cells, AP.EMU - associated grants
Associated scholarship(s):18/23430-4 - Evaluation of the potential of bevacizumab-functionalized liposomes or hyaluronic acid for incorporation of abiraterone in the treatment of prostate cancer, BP.PD
18/23442-2 - Evaluation of the potential of liposomes for co-encapsulation of Amphotericin B and micafungin in the treatment of systemic infection caused by Candida auris, BP.PD
18/08253-9 - Development and characterization of liquid-crystal phase nanodispersion as a multifunctional carrier system of TNF-alpha siRNA and Triptolide in the topical treatment of psoriasis, BP.MS

Scientific publications (29)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CE, RODRIGO; SILVA, RODRIGO CAMPOS; TRENTIN, DANIELLE SILVA; BARRETO DE MARCHI, JOAO GUILHERME; PAESE, KARINA; GUTERRES, SILVIA STANISCUASKI; MACEDO, ALEXANDRE JOSE; POHLMANN, ADRIANA RAFFIN. Galleria mellonella Larvae as an In Vivo Model to Evaluate the Toxicity of Polymeric Nanocapsules. Journal of Nanoscience and Nanotechnology, v. 20, n. 3, p. 1486-1494, MAR 2020. Web of Science Citations: 0.
PIVETTA, THAIS P.; SILVA, LETICIA B.; KAWAKAMI, CAMILA M.; ARAUJO, MARGARETE M.; DEL LAMA, MARIA PERPETUA F. M.; NAAL, ROSE MARY Z. G.; MARIA-ENGLER, SILVYA S.; GASPAR, LORENA R.; MARCATO, PRISCYLA D. Topical formulation of quercetin encapsulated in natural lipid nanocarriers: Evaluation of biological properties and phototoxic effect. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 53, OCT 2019. Web of Science Citations: 0.
SILVA, RUMMENIGGE OLIVEIRA; DA COSTA, BRUNA LOPES; DA SILVA, FLAVIA RODRIGUES; DA SILVA, CAROLINA NUNES; DE PAIVA, MAYARA BRANDAO; NUNES DOURADO, LAYS FERNANDA; MALACHIAS, ANGELO; DE SOUZA ARAUJO, ADRIANO ANTUNES; NUNES, PAULA SANTOS; SILVA-CUNHA, ARMANDO. Treatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone. International Journal of Pharmaceutics, v. 568, SEP 10 2019. Web of Science Citations: 0.
KRAVICZ, MARCELO H.; BALOGH, DEBORA T.; KAR, MRITYUNJOY; WEDEPOHL, STEFANIE; BENTLEY, MARIA VITORIA L. B.; CALDERON, MARCELO. Influence of Alkyl Chains of Modified Polysuccinimide-Based Polycationic Polymers on Polyplex Formation and Transfection. Macromolecular Bioscience, v. 19, n. 10 AUG 2019. Web of Science Citations: 0.
MIRANDA, MARIZA A.; MARCATO, PRISCYLA D.; CARVALHO, IVANA P. S.; SILVA, LETICIA B.; RIBEIRO, DIEGO L.; AMARAL, ROBSON; SWIECH, KAMILLA; BASTOS, JAIRO K.; PASCHOAL, JONAS A. R.; DOS REIS, RODOLFO B.; BENTLEY, MARIA V. L. B. Assessing the cytotoxic potential of glycoalkaloidic extract in nanoparticles against bladder cancer cells. Journal of Pharmacy and Pharmacology, v. 71, n. 10 AUG 2019. Web of Science Citations: 0.
ARBO, MARCELO DUTRA; ALTKNECHT, LOUISE F.; CATTANI, SHANDA; BRAGA, V, WESLEY; PERUZZI, CAROLINE P.; CESTONARO, V, LARISSA; GOETHEL, GABRIELA; DURAN, NELSON; GARCIA, SOLANGE CRISTINA. In vitro cardiotoxicity evaluation of graphene oxide. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v. 841, p. 8-13, MAY 2019. Web of Science Citations: 0.
BUSS, JULIETI HUCH; BEGNINI, KARINE RECH; BRUINSMANN, FRANCIELE ALINE; CEOLIN, TAISE; SONEGO, MARIANA SOUZA; POHLMANN, ADRIANA RAFFIN; GUTERRES, SILVIA STANISCUASKI; COLLARES, TIAGO; SEIXAS, FABIANA KOMMLING. Lapatinib-Loaded Nanocapsules Enhances Antitumoral Effect in Human Bladder Cancer Cell. FRONTIERS IN ONCOLOGY, v. 9, APR 9 2019. Web of Science Citations: 1.
DA SILVA, CAROLINA NUNES; DA SILVA, FLAVIA RODRIGUES; NUNES DOURADO, LAYS FERNANDA; MENDES DOS REIS, PABLO VICTOR; SILVA, RUMMENIGGE OLIVEIRA; DA COSTA, BRUNA LOPES; NUNES, PAULA SANTOS; AMARAL, FLAVIO ALMEIDA; DOS SANTOS, VERA LUCIA; DE LIMA, MARIA ELENA; CUNHA JUNIOR, ARMANDO DA SILVA. A New Topical Eye Drop Containing LyeTxI-b, A Synthetic Peptide Designed from A Lycosa erithrognata Venom Toxin, Was Effective to Treat Resistant Bacterial Keratitis. TOXINS, v. 11, n. 4 APR 2019. Web of Science Citations: 0.
FERREIRA, NATALIA NORONHA; CAETANO, BRUNO LEONARDO; BONI, FERNANDA ISADORA; SOUSA, FLAVIA; MAGNANI, MARINA; SARMENTO, BRUNO; FERREIRA CURY, BEATRIZ STRINGHETTI; DAFLON GREMIAO, MARIA PALMIRA. Alginate-Based Delivery Systems for Bevacizumab Local Therapy: In Vitro Structural Features and Release Properties. Journal of Pharmaceutical Sciences, v. 108, n. 4, p. 1559-1568, APR 2019. Web of Science Citations: 0.
CARDOSO, ALINE MARQUEZ; DE OLIVEIRA, EDILENE GADELHA; CORADINI, KARINE; BRUINSMANN, FRANCIELE ALINE; AGUIRRE, TANIRA; LORENZONI, RICARDO; SILVA BARCELOS, RAQUEL CRISTIANE; ROVERSI, KARINE; ROSSATO, DOMENIKA RUBERT; POHLMANN, ADRIANA RAFFIN; GUTERRES, SILVIA STANISCUASKI; BURGER, MARILISE ESCOBAR; RUVER BECK, RUY CARLOS. Chitosan hydrogels containing nanoencapsulated phenytoin for cutaneous use: Skin permeation/penetration and efficacy in wound healing. Materials Science & Engineering C-Materials for Biological Applications, v. 96, p. 205-217, MAR 2019. Web of Science Citations: 4.
CARDOSO, CIBELE; SERAFIM, RODOLFO B.; KAWAKAMI, AKINORI; PEREIRA, CRISTIANO GONCALVES; ROSZIK, JASON; VALENTE, VALERIA; VAZQUEZ, VINICIUS L.; FISHER, DAVID E.; ESPREAFICO, ENILZA M. The lncRNA RMEL3 protects immortalized cells from serum withdrawal-induced growth arrest and promotes melanoma cell proliferation and tumor growth. PIGMENT CELL & MELANOMA RESEARCH, v. 32, n. 2, p. 303-314, MAR 2019. Web of Science Citations: 1.
POUND-LANA, GWENAELLE E. N.; GARCIA, GIANI M.; TRINDADE, IZABEL C.; CAPELARI-OLIVEIRA, PATRICIA; PONTIFICE, THAIS GODINHO; VILELA, JOSE MARIO C.; ANDRADE, MARGARETH S.; NOTTELET, BENJAMIN; POSTACCHINI, BRUNA B.; MOSQUEIRA, VANESSA C. F. Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers: Probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres. Materials Science & Engineering C-Materials for Biological Applications, v. 94, p. 220-233, JAN 1 2019. Web of Science Citations: 2.
CARVALHO, I. P. S.; MIRANDA, M. A.; SILVA, L. B.; CHRYSOSTOMO-MASSARO, T. N.; PASCHOAL, J. A. R.; BASTOS, J. K.; MARCATO, P. D. IN VITRO Anticancer Activity and Physicochemical Properties of SOLANUM LYCOCARPUM Alkaloidic Extract Loaded in Natural Lipid-Based Nanoparticles. COLLOID AND INTERFACE SCIENCE COMMUNICATIONS, v. 28, p. 5-14, JAN 2019. Web of Science Citations: 2.
PORTAPILLA, GISELE BULHOES; PEREIRA, LUIZ MIGUEL; BRONZON DA COSTA, CASSIA MARIANA; PROVIDELLO, MAIARA VOLTARELLI; SAMPAIO OLIVEIRA, PEDRO ALEXANDRE; GOULART, AMANDA; ANCHIETA, NAIRA FERREIRA; WAINWRIGHT, MARK; LEITE BRAGA, GILBERTO UBIDA; DE ALBUQUERQUE, SERGIO. Phenothiazinium Dyes Are Active against Trypanosoma cruzi In Vitro. BIOMED RESEARCH INTERNATIONAL, 2019. Web of Science Citations: 0.
CALGAROTO, SELMA; FAURI, LUCAS E.; FRANK, LUIZA A.; PAESE, KARINA; GUTERRES, SILVIA S.; POHLMANN, ADRIANA R. Data of characterization and related assays of lipid-core nanocapsule formulations and their hydrolysis mechanism. DATA IN BRIEF, v. 21, p. 918-933, DEC 2018. Web of Science Citations: 2.
CALGAROTO, SELMA; FAURI, LUCAS E.; FRANK, LUIZA A.; PAESE, KARINA; GUTERRES, SILVIA S.; POHLMANN, ADRIANA R. Chemical stability, mass loss and hydrolysis mechanism of sterile and non-sterile lipid-core nanocapsules: The influence of the molar mass of the polymer wall. REACTIVE & FUNCTIONAL POLYMERS, v. 133, p. 161-172, DEC 2018. Web of Science Citations: 1.
DA SILVA, FLAVIA RODRIGUES; BRANDAO DE PAIVA, MAYARA RODRIGUES; NUNES DOURADO, LAYS FERNANDA; SILVA, RUMMENIGGE OLIVEIRA; DA SILVA, CAROLINA NUNES; DA COSTA, BRUNA LOPES; TOLEDO, CIBELE RODRIGUES; DE LIMA, MARIA ELENA; DA SILVA-CUNHA, ARMANDO. Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorio-allantoic membrane model. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, NOV 21 2018. Web of Science Citations: 1.
LAMAS DE SOUZA, SARAH OLIVEIRA; ANDRADE GUERRA, MARIA CAROLINA; DIAS HENEINE, LUIZ GUILHERME; DE OLIVEIRA, CAROLINA REIS; CUNHA JUNIOR, ARMANDO DA SILVA; FIALHO, SILVIA LIGORIO; OREFICE, RODRIGO LAMBERT. Biodegradable core-shell electrospun nanofibers containing bevacizumab to treat age-related macular degeneration. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 29, n. 11 NOV 2018. Web of Science Citations: 3.
DIAS, MARINA FRANCA; PINHEIRO DE FIGUEIREDO, BRUNA CAROLINE; TEIXEIRA-NETO, JULIA; ANDRADE GUERRA, MARIA CAROLINA; FIALHO, SILVIA LIGORIO; CUNHA, ARMANDO SILVA. In vivo evaluation of antitumoral and antiangiogenic effect of imiquimod-oaded polymeric nanoparticles. BIOMEDICINE & PHARMACOTHERAPY, v. 103, p. 1107-1114, JUL 2018. Web of Science Citations: 2.
MAGALHAES, MILENA C. R. S.; CASTRO, BRENDA F. M.; DE CASTRO, WHOCELY V.; BARROS, ANDRE L. B.; FERNANDES, RENATA S.; SILVA-CUNHA, ARMANDO; FIALHO, SILVIA L. Permeability and in vivo distribution of poly(epsilon-caprolactone) nanoparticles loaded with zidovudine. JOURNAL OF NANOPARTICLE RESEARCH, v. 20, n. 7 JUN 27 2018. Web of Science Citations: 0.
TOFANI, LARISSA BUENO; DEPIERI, LIVIA VIEIRA; CAMPOS, PATRICIA MAZUREKI; RIUL, THALITA BACHELLI; ANTONIETTO, KAMILLA SWIECH; DE ABREU FANTINI, MARCIA CARVALHO; LOPES BADRA BENTLEY, MARIA VITORIA. In Vitro TyRP-1 Knockdown Based on siRNA Carried by Liquid Crystalline Nanodispersions: an Alternative Approach for Topical Treatment of Vitiligo. PHARMACEUTICAL RESEARCH, v. 35, n. 5 MAY 2018. Web of Science Citations: 1.
GIACONE, DANIELA V.; CARVALHO, VANESSA F. M.; COSTA, SORAIA K. P.; LOPES, LUCIANA B. Evidence That P-glycoprotein Inhibitor (Elacridar)-Loaded Nanocarriers Improve Epidermal Targeting of an Anticancer Drug via Absorptive Cutaneous Transporters Inhibition. Journal of Pharmaceutical Sciences, v. 107, n. 2, p. 698-705, FEB 2018. Web of Science Citations: 4.
REMIAO, MARIANA H.; SEGATTO, NATALIA V.; POHLMANN, ADRIANA; GUTERRES, SILVIA S.; SEIXAS, FABIANA K.; COLLARES, TIAGO. The Potential of Nanotechnology in Medically Assisted Reproduction. FRONTIERS IN PHARMACOLOGY, v. 8, JAN 11 2018. Web of Science Citations: 4.
ANTONOW, MICHELLI B.; FRANCO, CAMILA; PRADO, WILLIAN; BECKENKAMP, ALINE; SILVEIRA, GUSTAVO P.; BUFFON, ANDREIA; GUTERRES, SILVIA S.; POHLMANN, ADRIANA R. Arginylglycylaspartic Acid-Surface-Functionalized Doxorubicin-Loaded Lipid-Core Nanocapsules as a Strategy to Target Alpha(V) Beta(3) Integrin Expressed on Tumor Cells. NANOMATERIALS, v. 8, n. 1 JAN 2018. Web of Science Citations: 2.
VICTORELLI, FRANCESCA DAMIANI; FIORAMONTI CALIXTO, GIOVANA MARIA; DOS SANTOS RAMOS, MATHEUS APARECIDO; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Metronidazole-Loaded Polyethyleneimine and Chitosan-Based Liquid Crystalline System for Treatment of Staphylococcal Skin Infections. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 14, n. 1, p. 227-237, JAN 2018. Web of Science Citations: 3.
FLAVIA RODRIGUES DA SILVA; MAYARA RODRIGUES BRANDÃO DE PAIVA; LAYS FERNANDA NUNES DOURADO; RUMMENIGGE OLIVEIRA SILVA; CAROLINA NUNES DA SILVA; BRUNA LOPES DA COSTA; CIBELE RODRIGUES TOLEDO; MARIA ELENA DE LIMA; ARMANDO DA SILVA-CUNHA. Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorioallantoic membrane model. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, p. -, 2018.
ROSA, JULIANA; SUZUKI, ISABELLA; KRAVICZ, MARCELO; CARON, ANGELO; PUPO, ANA VITORIA; GARCIA PRACA, FABIOLA; LOPES BADRA BENTLEY, MARIA VITORIA. Current Non-viral siRNA Delivery Systems as a Promising Treatment of Skin Diseases. CURRENT PHARMACEUTICAL DESIGN, v. 24, n. 23, p. 2644-2663, 2018. Web of Science Citations: 1.
LUCAS, CAROLINE G.; REMIAO, MARIANA H.; BRUINSMANN, FRANCIELE A.; LOPES, ISADORA A. R.; BORGES, MORGANA A.; FEIJO, ANA LAURA S.; BASSO, ANDREA CRISTINA; POHLMANN, ADRIANA R.; GUTERRES, SILVIA S.; CAMPOS, VINICIUS F.; SEIXAS, FABIANA K.; COLLARES, TIAGO. High doses of lipid-core nanocapsules do not affect bovine embryonic development &ITin vitro&IT. TOXICOLOGY IN VITRO, v. 45, n. 1, p. 194-201, DEC 2017. Web of Science Citations: 2.
SCHULTZE, EDUARDA; BUSS, JULIETI; CORADINI, KARINE; BEGNINI, KARINE RECH; GUTERRES, SILVIA S.; COLLARES, TIAGO; RUVER BECK, RUY CARLOS; POHLMANN, ADRIANA R.; SEIXAS, FABIANA KOMMLING. Tretinoin-loaded lipid-core nanocapsules overcome the triple-negative breast cancer cell resistance to tretinoin and show synergistic effect on cytotoxicity induced by doxorubicin and 5-fluororacil. BIOMEDICINE & PHARMACOTHERAPY, v. 96, p. 404-409, DEC 2017. Web of Science Citations: 8.

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