Modulation of phenotypic expression of monocyte subtypes and chemokine receptors in acute myocardial infarction by statins

• Grant number: 17/01368-2
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2017
• End date: July 31, 2019
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Carolina Nunes França
• Grantee: Carolina Nunes França
• Host Institution: Universidade de Santo Amaro (UNISA). São Paulo , SP, Brazil
• Associated researchers: Francisco Antonio Helfenstein Fonseca ; Maria Cristina de Oliveira Izar

Abstract

Atherosclerosis is a progressive disease, characterized by lipid and fibrotic element deposition in large caliber arteries. Conditions related to the development of atherosclerosis, as dyslipidemia, hypertension, diabetes and smoking are associated to endothelial dysfunction. There is frequent recurrence of cardiovascular outcomes after acute myocardial infarction and, at this sense, cycles of mobilization of monocyte subtypes (classical, intermediate and nonclassical) secondary to myocardial infarction may determine the colonization of atherosclerotic plaques in different stages of the development, contributing to early recurrence of ischemic events. The recruitment of different monocyte subsets during inflammatory process requires the expression of chemokine receptors CCR2, CCR5 and CX3CR1, to promote the migration of monocytes to the inflammatory site. This project aims to better understand the mechanisms related to the recovery of the ischemic myocardium and coronary disease progression. Specifically, we will study the monocyte subtypes (identification, quantification and phenotypic characterization) related to the early and late evolution of patients with acute myocardial infarction. In addition, the project will involve the expression of the chemokine receptors CCR2, CCR5 and CX3CR1, which have a role in the development of the atherosclerotic plaque. Pharmacological therapeutic strategies will be evaluated since the acute phase of myocardial infarction up to six months of clinical evolution. The better understanding of the differential role of monocyte subsets in the development of coronary disease may be a new strategic target for the comprehension and therapy of acute myocardial infarction. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE CARVALHO, DANIEL CARNEIRO; HELFENSTEIN FONSECA, FRANCISCO ANTONIO; DE OLIVEIRA IZAR, MARIA CRISTINA; PEREIRA ASSUNCAO SILVEIRA, ANA LUIZA; TULETA, IZABELA DOROTA; DO AMARAL, JONATAS BUSSADOR; NEVES, LUCAS MELO; LACERDA BACHI, ANDRE LUIS; FRANCA, CAROLINA NUNES. Monocytes presenting a pro-inflammatory profile persist in patients submitted to a long-term pharmacological treatment after acute myocardial infarction. FRONTIERS IN PHYSIOLOGY, v. 13, p. 11-pg., 2023-01-20. (12/51692-7, 17/01368-2)

DA SILVA, LEANDRO SANTOS; GERMANO, DANIELLE BORGES; FONSECA, FRANCISCO ANTONIO HELFENSTEIN; SHIO, MARINA TIEMI; NALI, LUIZ HENRIQUE DA SILVA; TULETA, IZABELA DOROTA; JULIANO, YARA; IZAR, MARIA CRISTINA DE OLIVEIRA; RIBEIRO, ANA PAULA; KATO, JULIANA TIEKO; et al. Persistence of a proinflammatory status after treatment of the acute myocardial infarction. Geriatrics & Gerontology International, v. 23, n. 9, p. 8-pg., 2023-07-31. (12/51692-7, 17/01368-2)

DOMINGOS, SIMONE APARECIDA; FRANCA, CAROLINA NUNES; TULETA, IZABELA; DA COSTA REZENDE BARBOSA, MARIANNE PENACHINI; LACERDA BACHI, ANDRE LUIS; NEVES, LUCAS MELO. Self-Care in Type 2 Diabetes Patients with Urgency Lower Limb Amputation: The Influence of Sex, Marital Status and Previous Amputations. PATIENT PREFERENCE AND ADHERENCE, v. 15, p. 1083-1090, 2021. (17/01368-2, 19/14115-0, 19/01020-1, 20/08869-0)