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Characterizing HCV primary resistance mutations for direct acting antiviral drug (DAA)

Grant number: 17/01809-9
Support type:Regular Research Grants
Duration: August 01, 2017 - July 31, 2019
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Regina Célia Moreira
Grantee:Regina Célia Moreira
Home Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Assoc. researchers:Fernanda de Mello Malta ; Gaspar Lisboa Neto ; João Renato Rebello Pinho ; Marcilio Figueiredo Lemos ; Maria Cássia Jacintho Mendes Corrêa


Chronic infection with hepatitis C virus affects about 160 million people worldwide and it is leading cause of cirrhosis and other complications. The recent understanding HCV life cycle make possible the development of new drugs; target the viral replication process, such structural proteins like NS3/NS5A and NS5B. Direct acting antiviral drug (DAA) promises to open a new era in treating chronic HCV The emergence of drug-resistant strains of HCV has resulted in the failure of many therapeutic strategies. The aim of this study was to screen resistance mutations for responses for direct acting antiviral drug NS3/ NS5A and NS5B in samples from patients following in a public health laboratory in the State of São Paulo, before the beginning the therapy. Will include a samples of serum from patients with chronic HCV infection, genotyping 1a and 1b, who were starting or following-up public health service treatment and they had never received treatment. PCR and sequence from specifically genome fragment will be done from HCV. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOREIRA, REGINA CELIA; DE TORRES SANTOS, ANA PAULA; LISBOA-NETO, GASPAR; JACINTHO MENDES-CORREA, MARIA CASSIA; LEMOS, MARCILIO FIGUEIREDO; MALTA, FERNANDA MELLO; FERRAZ SANTANA, RABIA ANITA; FERNANDO DASTOLI, GREGORIO TADEU; DUARTE DE CASTRO, VANESSA FUSCO; REBELLO PINHO, JOAO RENATO. Prevalence of naturally occurring amino acid substitutions associated with resistance to hepatitis C virus NS3/NS4A protease inhibitors in Sao Paulo state. ARCHIVES OF VIROLOGY, v. 163, n. 10, p. 2757-2764, OCT 2018. Web of Science Citations: 0.

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