New frontiers in the fight against obesity: digital health education as supporting in the interdisciplinary clinical process

• Grant number: 17/07372-1
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2017
• End date: August 31, 2019
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Ana Raimunda Dâmaso
• Grantee: Ana Raimunda Dâmaso
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Lila Missae Oyama

Abstract

Obesity is characterized as a complex, multifactorial and chronic disease, with biological and social consequences that trigger several comorbidities that decrease quality and life expectancy. Increasing numbers of with obesity suggest the development of lifestyle interventions designed to regulate the energy balance that often clash with motivational problems, environmental and personal barriers, hampering the success, implementation, and adherence to programs. In this perspective, electronic media and easy access to the internet can be allied with structured weight loss programs scientifically based on the addition of numerous educational, control and communication tools. Objective: The main objective of this study is to verify the influence of the multidisciplinary intervention with lifestyle guidelines in obese adult women with educational health program based online platform. Methodology: 300 obese adult women, aged 20 to 45 years, classified as obese according to Body Mass Index (BMI) will be selected. The volunteers will undergo 12 weeks of multidisciplinary therapy with clinical assessment, dietary guidance and physical activity, with online support through emails, WhatsApp®, social media and videos with educational themes on obesity in an online platform. After the selection (baseline) and the intervention period, the patients will perform the analysis of body composition, physical activity level analysis, biochemical analyzes (glucose, insulin, lipid profile - total cholesterol, fractions and triglycerides, energy balance markers - Adiponectin, leptin, NPY, and the cellular transdifferentiation markers - FGF-21 and atrial natriuretic peptide) and blood pressure (BP). The insulin resistance (HOMA-IR) and insulin sensitivity (QUICKI) will be calculated. The protocol will be composed of tree face-to-face sessions with group support that will address the difficulties encountered in lifestyle, including eating habits, exercise and motivation throughout the protocol by electronic means. In these meetings the questionnaires will be applied to investigate the symptoms of depression, anxiety, bulimia, body self-image, mood alteration, physical activity level, food frequency, metabolic tracing, eating habits, food registry of three days, quality of life and anthropometric measures of weight, height, circumferences, BP and body composition. In the non-presential weeks, the weight will be monitored by self-report and at the end of each week, the volunteers will answer a quiz of questions about the topics worked. Post-intervention weight regimens will be analyzed electronically for 12 and 24 weeks following studies. The results will be analyzed using Statistica software version 7.0. The normality of the data will be verified and the behavior of the variables during the intervention performed by the ANOVA test for repeated measures with adopting p d 0.05. The dependency behavior of the variables will be verified by simple linear regression. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS FERREIRA, YASMIN ALABY; PELISSARI KRAVCHYCHYN, ANA CLAUDIA; FERREIRA VICENTE, SOFIA DE CASTRO; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; TOCK, LIAN; OYAMA, LILA MISSAE; BOLDARINE, VALTER TADEU; LANDI MASQUIO, DEBORAH CRISTINA; DAMASO, ANA R.. Influence of magnitude of weight loss on Adipo/lep ratio in adolescents with obesity undergoing multicomponent therapy. CYTOKINE, v. 131, JUL 2020. (17/07372-1)

DAMASO, ANA RAIMUNDA; MACHADO, PAOLA PROSPERO; RHEIN, SAMANTHA OTTANI; LANDI MASQUIO, DEBORAH CRISTINA; OYAMA, LILA MISSAE; BOLDARINE, VALTER TADEU; DE OLIVEIRA, GABRIELA IERVOLINO; TOCK, LIAN; THIVEL, DAVID; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ. Effects of an interdisciplinary weight loss program on fibroblast growth factor 21 and inflammatory biomarkers in women with overweight and obesity. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 65, n. 6, p. 821-831, NOV-DEC 2021. (15/14309-9, 17/07372-1)

SHIBA, CAROLINA KIM; DAMASO, ANA RAIMUNDA; RHEIN, SAMANTHA OTTANI; MACHADO, PAOLA PROSPERO; LANDI MASQUIO, DEBORAH CRISTINA; OYAMA, LILA MISSAE; BARRETO LOMBARDI, JOAO AUGUSTO; LO DUCA, LEONARDO; TOCK, LIAN; OLIVEIRA, GABRIELA IERVOLINO; et al. Interdisciplinary therapy had positive effects on inflammatory state, mediated by leptin, adiponectin, and quality of diet in obese women. NUTRICION HOSPITALARIA, v. 37, n. 3, p. 456-464, MAY-JUN 2020. (15/14309-9, 17/07372-1)

AGOSTINIS-SOBRINHO, CESAR; RAMIREZ-VELEZ, ROBINSON; NORKIENE, SIGUTE; DAMASO, ANA; GANEN, ALINE DE PIANO; LANDI MASQUIO, DEBORAH C.; RAUCKIEN-MICHAELSSON, ALONA; MOTA, JORGE; SANTOS, RUTE. Association of Adipocytokines and Inflammatory Biomarkers with Blood Pressure in Adolescents: A Longitudinal Analysis. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 30, n. 12, p. 2296-2302, NOV 27 2020. (17/07372-1, 11/50414-0, 15/14309-9, 13/08522-6)

PELISSARI KRAVCHYCHYN, ANA CLAUDIA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CORGOSINHO, FLAVIA CAMPOS; LANDI MASQUIO, DEBORAH CRISTINA; DE CASTRO FERREIRA VICENTE, SOFIA EMANUELLE; MARTINS FERREIRA, YASMIN ALABY; SILVA, PATRICIA LEAO; GANEN, ALINE DE PIANO; OYAMA, LILA MISSAE; TOCK, LIAN; et al. The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents. ANNALS OF NUTRITION AND METABOLISM, v. 72, n. 4, p. 279-286, 2018. (17/07372-1, 13/19046-0, 13/08522-6)

PELISSARI KRAVCHYCHYN, ANA CLAUDIA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; MARTINS FERREIRA, YASMIN ALABY; DE CASTRO FERREIRA VICENTE, SOFIA EMANUELLE; CORGOSINHO, FLAVIA CAMPOS; OYAMA, LILA MISSAE; BOLDARINE, VALTER TADEU; TOCK, LIAN; THIVEL, DAVID; DAMASO, ANA RAIMUNDA. he Role of ANP Level Response in Interdisciplinary Weight Loss Therapy on Cardiometabolic Risk and Body Composition in Adolescents with Obesit. Arquivos Brasileiros de Cardiologia, v. 118, n. 1, p. 33-39, 2022. (17/07372-1, 11/50414-0, 15/14309-9)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; CORGOSINHO, FLAVIA CAMPOS; CARANTI, DANIELLE ARISA; GANEN, ALINE DE PIANO; TOCK, LIAN; OYAMA, LILA MISSAE; DAMASO, ANA RAIMUNDA. Effects of magnitude of visceral adipose tissue reduction: Impact on insulin resistance, hyperleptinemia and cardiometabolic risk in adolescents with obesity after long-term weight-loss therapy. Diabetes & Vascular Disease Research, v. 16, n. 2, SI, p. 196-206, MAR 2019. (15/14309-9, 11/50414-0, 13/08522-6, 17/07372-1)

MARTINS FERREIRA, YASMIN ALABY; PELISSARI KRAVCHYCHYN, ANA CLAUDIA; FERREIRA VICENTE, SOFIA DE CASTRO; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; TOCK, LIAN; OYAMA, LILA MISSAE; BOLDARINE, VALTER TADEU; LANDI MASQUIO, DEBORAH CRISTINA; THIVEL, DAVID; SHIVAPPA, NITIN; et al. An Interdisciplinary Weight Loss Program Improves Body Composition and Metabolic Profile in Adolescents With Obesity: Associations With the Dietary Inflammatory Index. FRONTIERS IN NUTRITION, v. 6, JUN 3 2019. (17/07372-1)

AGOSTINIS-SOBRINHO, CESAR; DE CASTRO FERREIRA VICENTE, SOFIA EMANUELLE; KIEVISIENE, JUSTINA; LOPES, LUIS; DAMASO, ANA RAIMUNDA; NORKIENE, SIGUTE; ROSARIO, RAFAELA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; RAMIREZ-VELEZ, ROBINSON; MOTA, JORGE; et al. High levels of adiponectin attenuate the detrimental association of adiposity with insulin resistance in adolescents. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 30, n. 5, p. 822-828, MAY 7 2020. (17/07372-1, 15/14309-9, 13/08522-6, 11/50414-0)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; MOREIRA, CARLOS E.; DA SILVA, PATRICIA LEAO; LANDI MASQUIO, DEBORAH C.; CORGOSINHO, FLAVIA CAMPOS; PELISSARI KRAVCHYCHYN, ANA C.; DE CASTRO FERREIRA VICENTE, SOFIA E.; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO T.; et al. The effect of aerobic plus resistance training associated with a long-term interdisciplinary weight loss program on visceral fat and isokinetic parameters in adolescents with obesity. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, v. 60, n. 6, p. 855-863, JUN 2020. (11/50414-0, 17/07372-1, 15/14309-9, 13/08522-6)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; CORGOSINHO, FLAVIA CAMPOS; CARANTI, DANIELLE ARISA; GANEN, ALINE DE PIANO; TOCK, LIAN; OYAMA, LILA MISSAE; DAMASO, ANA RAIMUNDA. Effects of magnitude of visceral adipose tissue reduction: Impact on insulin resistance, hyperleptinemia and cardiometabolic risk in adolescents with obesity after long-term weight-loss therapy. Diabetes & Vascular Disease Research, v. 16, n. 2, p. 11-pg., 2019-03-01. (15/14309-9, 17/07372-1, 13/08522-6, 11/50414-0)