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Biologically active peptides against pathogenic microorganisms and cancer cells

Abstract

Antimicrobial peptides (PAMs) are biomolecules with less than 100 amino acid residues that play an important role in the immune response of various microorganisms such as bacteria, fungi and viruses, as well as being potential anticancer agents. Thus, it is very important searching new bioactive compounds. The present project proposes the synthesis of new AMPs, analogues of VmCT1 and Polybia-CP and of hybrid sequences of these with the AMPs (Protonectin, Anoplin, Decoralin, Temporin A, CM-15, Cecropin A (1-13) and Melittin), in the attempt to increase the antimicrobial and antitumoral activities of these substances, without presenting relevant hemolytic activity. Analogs will be synthesized by solid phase method, purified by HPLC and characterized by LC/ESI-MS. Biological assays will be performed on several strains of bacteria and fungi, and some cancer cells to verify the antimicrobial and anticancer activities, respectively. Conformational studies will be performed by Circular Dichroism (CD) and probably by nuclear magnetic resonance (NMR). (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Enhanced scorpion venom molecules can be used to treat Chagas disease  
Articles published in other media outlets (20 total):
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Plantão News (MT): Moléculas com potencial para combater a doença de Chagas mimetizam toxina do veneno de escorpião (08/Apr/2021)
Saense: Moléculas com potencial para combater a doença de Chagas mimetizam toxina do veneno de escorpião (08/Apr/2021)
Meio Norte online (Piauí): Moléculas combatem doença de Chagas e veneno de escorpião (07/Apr/2021)
Blog Jornal da Mulher: Moléculas com potencial para combater a doença de Chagas mimetizam toxina do veneno de escorpião (07/Apr/2021)
Portal da Enfermagem: Moléculas com potencial para combater a doença de Chagas mimetizam toxina do veneno de escorpião (07/Apr/2021)
Quimiweb: Moléculas com potencial para combater a doença de Chagas mimetizam toxina do veneno de escorpião (07/Apr/2021)
Diario Salud (República Dominicana): Moléculas del veneno de escorpión pueden ayudar a combatir el mal de Chagas (07/Jan/2021)
Mundo de la Salud: Moléculas del veneno de escorpión pueden ayudar a combatir el mal de Chagas (05/Jan/2021)
iPaperz (EUA): Enhanced Scorpion Venom Molecules Can Be Used To Treat Chagas Disease (04/Jan/2021)
Medindia (Índia): Scorpion Venom Helps Treat Chagas Disease (25/Dec/2020)
Programa InfoSalud (Argentina): El mejoramiento de moléculas de veneno de escorpión puede ayudar en el combate contra el mal de Chagas (23/Dec/2020)
Medical Xpress (Reino Unido): Enhanced scorpion venom molecules can be used to treat Chagas disease (21/Dec/2020)
Science Codex: Enhanced scorpion venom molecules can be used to treat Chagas disease (21/Dec/2020)
Scienmag Science Magazine (Reino Unido): Enhanced Scorpion Venom Molecules Can Be Used To Treat Chagas Disease (21/Dec/2020)
Brightsurf: Enhanced Scorpion Venom Molecules Can Be Used To Treat Chagas Disease (21/Dec/2020)
7thSpace: Enhanced scorpion venom molecules can be used to treat Chagas disease (21/Dec/2020)
Free Republic (EUA): Enhanced scorpion venom molecules can be used to treat Chagas disease (21/Dec/2020)
News Break (EUA): Enhanced scorpion venom molecules can be used to treat Chagas disease (21/Dec/2020)
Health910: Enhanced Scorpion Venom Molecules Can Be Used To Treat Chagas Disease (21/Dec/2020)
The Uncover Reality (Índia): Enhanced Scorpion Venom Molecules Can Be Used to Treat Chagas Disease (Medicine) (21/Dec/2020)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEDRON, CIBELE NICOLASKI; SILVA, ADRIANA FARIAS; TORRES, MARCELO DER TOROSSIAN; DE OLIVEIRA, CYNTIA SILVA; ANDRADE, GISLAINE PATRICIA; CERCHIARO, GISELLE; PINHAL, MARIA APARECIDA SILVA; DE LA FUENTE-NUNEZ, CESAR; OLIVEIRA JUNIOR, VANI XAVIER. Net charge tuning modulates the antiplasmodial and anticancer properties of peptides derived from scorpion venom. JOURNAL OF PEPTIDE SCIENCE, v. 27, n. 4 JAN 2021. Web of Science Citations: 0.
PEDRON, CIBELE NICOLASKI; FREIRE, KATIELLE ALBUQUERQUE; TORRES, MARCELO DER TOROSSIAN; LIMA, DANYA BANDEIRA; MONTEIRO, MARILIA LOPES; PESSOA BEZERRA DE MENEZES, RAMON ROSEO PAULA; COSTA MARTINS, ALICE MARIA; OLIVEIRA JUNIOR, VANI XAVIER. Arg-substituted VmCT1 analogs reveals promising candidate for the development of new antichagasic agent. Parasitology, v. 147, n. 14, p. 1810-1818, DEC 2020. Web of Science Citations: 1.
FREIRE, KATIELLE ALBUQUERQUE; TORRES, MARCELO DER TOROSSIAN; LIMA, DANYA BANDEIRA; MONTEIRO, MARILIA LOPES; PESSOA BEZERRA DE MENEZES, RAMON ROSEO PAULA; COSTA MARTINS, ALICE MARIA; OLIVEIRA JR, VANI XAVIER. Wasp venom peptide as a new antichagasic agent. Toxicon, v. 181, p. 71-78, JUL 15 2020. Web of Science Citations: 0.
CHICA ACEVEDO, ISABEL CRISTINA; SILVA, JR., PEDRO ISMAEL; SILVA, FERNANDA DIAS; ARAUJO, IRIS; ALVES, FLAVIO LOPES; OLIVEIRA, CYNTIA SILVA; OLIVEIRA, JR., VANI XAVIER. IsCT-based analogs intending better biological activity. JOURNAL OF PEPTIDE SCIENCE, OCT 2019. Web of Science Citations: 0.
PEDRON, CIBELE NICOLASKI; ARAUJO, IRIS; DA SILVA JUNIOR, PEDRO ISMAEL; DA SILVA, FERNANDA DIAS; TOROSSIAN TORRES, MARCELO DER; OLIVEIRA JUNIOR, VANI XAVIER. Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens. BIOORGANIC CHEMISTRY, v. 90, n. SI SEP 2019. Web of Science Citations: 0.
PEDRON, CIBELE NICOLASKI; DE OLIVEIRA, CYNTIA SILVA; DA SILVA, ADRIANA FARIAS; ANDRADE, GISLAINE PATRICIA; DA SILVA PINHAL, MARIA APARECIDA; CERCHIARO, GISELLE; DA SILVA JUNIOR, PEDRO ISMAEL; DA SILVA, FERNANDA DIAS; TORRESD, MARCELO DER TOROSSIAN; OLIVEIRA, VANI XAVIER. The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1. European Journal of Pharmaceutical Sciences, v. 136, AUG 1 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação 62/734,298 - Massachusetts Institute of Technology (MIT) ; Universidade Federal do ABC (UFABC) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - September 2018, 21