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Impact of transplacental exposure to tobacco smoke in the DNA of newborn: genetic and epigenetic effects

Grant number: 14/19914-5
Support type:Regular Research Grants
Duration: September 01, 2017 - August 31, 2020
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Cooperation agreement: Fundação para a Ciência e a Tecnologia (FCT)
Principal researcher:Fernando Barbosa Júnior
Grantee:Fernando Barbosa Júnior
Principal researcher abroad: Carla Sofia Trindade Da Costa
Institution abroad: Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Bruno Alves Rocha ; Gustavo Rafael Mazzaron Barcelos ; João Paulo Fernandes Teixeira ; Solange Cristina Bastos da Costa ; Stefano Banassi

Abstract

Over the years, it became also clear that tobacco use in pregnant women increases the risk of different health problems not only in mother but also the fetus. Nevertheless, few studies have examined the influence of environmental tobacco smoke (ETS) during pregnancy on the newborn health.The present study aims to assess the damage in DNA and changes in patterns of DNA methylation and histone modifications in newborns resulting from in utero exposure to ETS. Study population will include pregnant women and newborns of Porto district being analyzed different samples in order to obtain information concerning the consequences of transplacental exposure to ETS on newborns DNA. In order to address simultaneous exposure to other DNA-damaging chemicals, a wide number of chemicals will also be analyzed in biological matrices.A deep characterization of early-life exposure to a wide range of chemicals and its association with genetics and epigenetics in the newborn is the main purpose of this study.The information collected can provide relevant information to awareness campaigns and provide scientific support for the possible implementation of coherent measures for disease prevention in early stages of life. Moreover, the results provide scientific support for the possible implementation of coherent and effective health promotion and disease prevention in early stages of life in order to optimize the current and future health not only of women but also their children. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRUNO ALVES ROCHA; MARIANA ZUCCHERATO BOCATO; ELDER FRANCISCO LATORRACA; JOÃO PAULO BIANCHI XIMENEZ; FERNANDO BARBOSA JR. A SURVEY OF PARABENS IN COMMERCIAL BABY WIPES FROM BRAZIL AND ESTIMATION OF DAILY EXPOSURE. Química Nova, v. 43, n. 4, p. 442-446, Abr. 2020. Web of Science Citations: 0.
ROCHA, BRUNO ALVES; DE OLIVEIRA, SILVANA RUELLA; DA SILVA, RODRIGO MOREIRA; MAZZARON BARCELOS, GUSTAVO RAFAEL; MORAES DE OLIVEIRA, ANDERSON RODRIGO; BARBOSA JR, FERNANDO. An eco-friendly sample preparation procedure base on low-density solvent-based air-assisted liquid-liquid microextraction for the simultaneous determination of 21 potential endocrine disruptors in urine samples by liquid chromatography-tandem mass spectrometry. Microchemical Journal, v. 147, p. 207-214, JUN 2019. Web of Science Citations: 1.
DE OLIVEIRA, MARIANA LEPRI; ROCHA, BRUNO ALVES; DE OLIVEIRA SOUZA, VANESSA CRISTINA; BARBOSA, JR., FERNANDO. Determination of 17 potential endocrine-disrupting chemicals in human saliva by dispersive liquid-liquid microextraction and liquid chromatography-tandem mass spectrometry. Talanta, v. 196, p. 271-276, MAY 1 2019. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.