| Grant number: | 17/14880-3 |
| Support Opportunities: | Regular Research Grants |
| Start date: | October 01, 2017 |
| End date: | September 30, 2019 |
| Field of knowledge: | Health Sciences - Dentistry |
| Principal Investigator: | Oslei Paes de Almeida |
| Grantee: | Oslei Paes de Almeida |
| Host Institution: | Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil |
Abstract
Follicular lymphoid hyperplasias (FLH) are seldom diagnosed in the oral cavity; however, only few case reports are available in literature, avoiding a better understanding of this entity that is difficult to be distinguished from extranodal non-Hodgkin lymphomas. Approximately, 3 to 5% of all lymphomas are identified in the oral cavity, and the diffuse large B cell lymphoma not otherwise specified (DLBCL NOS) is the most common subtype; nevertheless, very few is understood regarding the clinicopathological and molecular factors that determine the patients' survival. T cell-derived lymphomas are very rare in the oral cavity, and extranodal NK/T cell lymphoma nasal type (ENKTCL NT) is one of the most aggressive subtypes; however, large case series that could provide a better understanding of its clinicopathological and immunohistochemical characteristics are rare. Therefore, the aim of this study is to determine the clinicopathological, immunohistochemical and prognostic features of FLH, DLBCL NOS and ENKTCL NT of the oral cavity. For that, 20 cases of FLH, 90 cases of oral B lymphomas (30 DLBCL NOS, 30 low grade lymphomas and 30 high grade lymphomas different from DLBCL NOS), 30 cases of nodal DLBCL NOS and 70 cases of ENKTCL NT, all of them formalin-fixed and paraffin-embedded cases, will be retrospectively retrieved in the period from 2000 to 2015. Clinicopathological and demographic data will be retrieved from the patients' medical charts. New histological sections, the immunohistochemical profile of each case and in situ hybridization reactions against Epstein-Barr virus will be done or reviewed to confirm the original diagnoses. By the end of this project we look forward to better comprehending the biological behavior of this important group of lesions that affects the oral cavity. (AU)
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