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Determination of ADAM10 and ADAM17 metalloproteinase activity on extracellular vesicles

Grant number: 17/12560-1
Support type:Research Grants - Visiting Researcher Grant - International
Duration: October 08, 2018 - November 02, 2018
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Adriana Franco Paes Leme
Grantee:Adriana Franco Paes Leme
Visiting researcher: Hinrich Hansen
Visiting researcher institution: University of Cologne (UoC), Germany
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Campinas , SP, Brazil

Abstract

Visite Plan: 1. Seminar at LNBio on the 'Role of ectodomain shedding of signaling proteins on extracellular vesicle for the tumor-supporting communication between cancer and supporter cells - options for targeted cancer therapy'. 2. Laboratory work: Introduction and help in establishing a test system to determine the metalloproteinase activity on the surface of extracellular vesicles. The test is running in my lab in Cologne/Germany and I will help to establish this method at LNBio in Campinas. For that purpose, I will bring reagents, in particular selective, novel fluorescent substrates and help testing and evaluating the various samples from LNBio. 3. Meetings with other groups in SP (UNICAMP, USP, UNIFESP) to intensify existing collaborations and create a new collaborative research initiative on the 'Role of cancer cell EVs in tolerance induction within the tumor microenvironment'. We plan to create structures for a longlasting stable scientific cooperation, including student exchange between Cologne/Germany and São Paulo/BR. (AU)