Effects of the inclusion of a functional circuit to aerobic and resistance training on functionality, physical activity in daily life and immuno-metabolic response of patients with COPD: a randomized clinical trial with follow-up

• Grant number: 17/10145-7
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2017
• End date: July 31, 2020
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Ercy Mara Cipulo Ramos
• Grantee: Ercy Mara Cipulo Ramos
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Associated researchers: Ana Paula Rabelo ; Berta Lúcia de Mendonça Silva ; Carlos Augusto Marçal Camillo ; Dionei Ramos ; Fabiano Francisco de Lima ; Fernando Zandonadi ; Franciele Marques Vanderlei ; Isis Grigoletto Silva ; Juliana Souza Uzeloto ; Rebeca Nunes Silva ; Thiago Pereira Veronese
• Associated research grant(s): 18/15130-0 - The effects of elastic resistance training in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis, AP.R SPRINT
• Associated scholarship(s): 18/20981-0 - Effects of the inclusion of a functional circuit to aerobic and resistance training on physical activity in daily life and functionality of patients with COPD: a randomized clinical trial with follow-up, BP.TT; 17/27019-4 - Effects of the inclusion of a functional circuit to aerobic and resistance training on physical activity in daily life and functionality of patients with COPD: a randomized clinical trial with follow-up, BP.TT

Abstract

Introduction: Functional training has been shown to be a viable alternative in the rehabilitation of patients with chronic obstructive pulmonary disease (COPD). However the effects of the insertion of this type of training into the combined training (aerobic and resistance) commonly performed in the Pulmonary Rehabilitation Programs (RP) are still not clear Aims: To evaluate the effects of the inclusion of a functional circuit to the combined training (aerobic and resistance) in the short term on the functionality and level of physical activity in daily life (PADL) of patients with COPD. Also, to evaluate the immuno-metabolic profile, acceptability and satisfaction to training, as well as to follow up the PADL and functionality three months after training. Methods: Patients with COPD will be randomized to an 8-week training program with 3 weekly sessions, including resistance training, aerobic and functional circuit (FCG), conventional training (resistance and aerobic) (CTG) or to a usual care group (UCG). Before and at the end of the training programs, patients will be evaluated regarding functionality, Immuno-metabolic profile and PADL. Qualiquantitative evaluation of acceptability and satisfaction will occur at the end of training. A follow-up of three months after training will be performed evaluating the PADL and functionality. Statistical analysis: Data distribution will be verified by Kolmogorov-Smirnov test. Two-way ANOVA will be performed to evaluate intra and inter-group differences. Data of acceptability and satisfaction will be evaluated using verbatim transcripts (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE LIMA, FABIANO F.; CAVALHERI, VINICIUS; SILVA, BRUNA S. A.; GRIGOLETTO, ISIS; UZELOTO, JULIANA S.; RAMOS, DIONEI; CAMILLO, CARLOS A.; RAMOS, ERCY M. C.. Elastic Resistance Training Produces Benefits Similar to Conventional Resistance Training in People With Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis. PHYSICAL THERAPY, v. 100, n. 11, p. 1891-1905, NOV 2020. (18/04871-0, 17/10145-7, 18/15130-0, 18/04870-3)

DE LIMA, FABIANO FRANCISCO; CAMILLO, CARLOS AUGUSTO MARCAL; GRIGOLETTO, ISIS; UZELOTO, JULIANA; VANDERLEI, FRANCIELE MARQUES; RAMOS, DIONEI; BURTIN, CHRIS; RAMOS, ERCY MARA CIPULO. Combining functional exercises with exercise training in COPD: a randomized controlled trial. PHYSIOTHERAPY THEORY AND PRACTICE, v. N/A, p. 10-pg., 2022-12-03. (18/04871-0, 17/10145-7)

GRIGOLETTO, ISIS; LIMA, FABIANO FRANCISCO DE; ETO, DANIELE AKEMI; SUZUKI, NATALIA NARUMI VOLTARELI; UZELOTO, JULIANA SOUZA; RAMOS, ERCY MARA CIPULO. Satisfaction and Adherence of COPD Patients to a Conventional Training Associated with Functional Exercises and to a Conventional Training Isolated: A Qualiquantitative Study. PATIENT PREFERENCE AND ADHERENCE, v. 16, p. 14-pg., 2022-01-01. (17/10145-7, 17/10925-2)

UZELOTO, JULIANA SOUZA; DE TOLEDO-ARRUDA, ALESSANDRA CHOQUETA; DE ALENCAR SILVA, BRUNA SPOLADOR; GOLIM, MARJORIE DE ASSIS; MARQUES BRAZ, ALINE MARCIA; DE LIMA, FABIANO FRANCISCO; GRIGOLETTO, ISIS; CIPULO RAMOS, ERCY MARA. Systemic Cytokine Profiles of CD4+T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 15, p. 2931-2940, 2020. (17/10145-7, 18/04870-3)

UZELOTO, JULIANA SOUZA; DE TOLEDO-ARRUDA, ALESSANDRA CHOQUETA; DE ALENCAR SILVA, BRUNA SPOLADOR; GOLIM, MARJORIE DE ASSIS; MARQUES BRAZ, ALINE MARCIA; DE LIMA, FABIANO FRANCISCO; GRIGOLETTO, ISIS; CIPULO RAMOS, ERCY MARA. Systemic Cytokine Profiles of CD4+T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 15, p. 10-pg., 2020-01-01. (18/04870-3, 17/10145-7)

DE ALENCAR SILVA, BRUNA S.; LIRA, FABIO S.; ROSSI, FABRICIO E.; RAMOS, DIONEI; UZELOTO, JULIANA S.; FREIRE, ANA P. C. F.; DE LIMA, FABIANO F.; GOBBO, LUIS A.; RAMOS, ERCY M. C.. Inflammatory and Metabolic Responses to Different Resistance Training on Chronic Obstructive Pulmonary Disease: A Randomized Control Trial. FRONTIERS IN PHYSIOLOGY, v. 9, MAR 23 2018. (15/13353-4, 17/10145-7)

DE LIMA, FABIANO FRANCISCO; CAMILLO, CARLOS AUGUSTO; GRIGOLETTO, ISIS; UZELOTO, JULIANA SOUZA; VANDERLEI, FRANCIELE MARQUES; RAMOS, DIONEI; CIPULO RAMOS, ERCY MARA. Effects of combining functional exercises with exercise training on daily physical activities and functionality in patients with COPD: a protocol for a randomized clinical trial. Trials, v. 20, n. 1, DEC 5 2019. (17/10145-7, 17/10925-2, 18/04871-0)

UZELOTO, J.; DE TOLEDO-ARRUDA, A. C.; SILVA, SPOLADOR DE ALENCAR B.. Effect of physical training on cytokine expression in CD4+ T lymphocytes in subjects with stable COPD (vol 16, pg 1, 2022). THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, v. 16, p. 1-pg., 2022-07-01. (19/16004-1, 17/10145-7, 21/04198-6, 18/04870-3)

UZELOTO, JULIANA S.; DE TOLEDO-ARRUDA, ALESSANDRA C.; SILVA, BRUNA S. A.; BRAZ, ALINE M. M.; DE LIMA, FABIANO F.; GRIGOLETTO, ISIS; RAMOS, DIONEI; GOLIM, MARJORIE A.; RAMOS, ERCY M. C.. Effect of physical training on cytokine expression in CD4+T lymphocytes in subjects with stable COPD. THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, v. 16, p. 11-pg., 2022-06-01. (18/04870-3, 17/10145-7)