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The role of the cysteine and glycine-rich protein-3 (CRP3) in mechanosensing of cardiovascular smooth muscle cells

Abstract

About 8% of men aged over 65 years show abdominal aortic aneurysms (AAA) and over 80% of patients where and AAA are ruptured die. The AAA formation involves the rupture of extracellular matrix fibers and loss of smooth muscle cells leading to the vascular wall narrowing. The underlying molecular mechanisms of how AAA develops are unknown. During the aneurysm development, there is an increase of mechanical stress in the vascular wall due to the decrease of smooth muscle cells and extracellular matrix (ECM) content. This proposal aims to shed more light into the function of the protein CRP3 (cysteine and glycine-rich protein-3) and how it regulates the cellular response to mechanical strain. Following striking pilot data, we hypothesize that CRP3 mediates its function through components of cell-matrix interaction sites. To examine this hypothesis we will employ state-of-the-art-advanced fluorescence imaging and analyses how CRP3 contributes to molecular dynamics and interactions of the adhesion complex proteins under mechanical stimuli smooth muscle cells experience in vivo. The collaboration will help the team members involved in this project to gain, (I) valuable data that enable to expand the collaboration and submit a follow up grant application of larger scope; (II) to interdisciplinary insight into the methods applied by the partner laboratory; (III) to potentially expend the collaborative efforts to other laboratories situated in the Universities. A lona-term aim will be to help identifying necessary new targets of how to prevent and treat AAA. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Proteína pode aumentar a durabilidade das pontes de safena 
Una proteína para aumentar la durabilidad del baipás 
Protein could extend saphenous vein graft durability 
Articles published in other media outlets (19 total):
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UOL: Proteína pode aumentar a durabilidade das pontes de safena (16/Sep/2019)
Science and Technology Research News (EUA): Protein Could Extend Saphenous Vein Graft Durability (11/Nov/2019)
Al Día (Cuba): Una proteína para aumentar la durabilidad del baipás (07/Nov/2019)
Sitios Fuente (México): Una proteína para aumentar la durabilidad del baipás (12/Oct/2019)
ElChaco.info (Bolívia): Una proteína para aumentar la durabilidad del baipás (12/Oct/2019)
NCYT Amazings (Espanha): Una proteína para aumentar la durabilidad del baipás (11/Oct/2019)
EresViral (República Dominicana): Una proteína para aumentar la durabilidad del baipás (11/Oct/2019)
Infomediatico: Una proteína para aumentar la durabilidad del baipás (11/Oct/2019)
Jornal do Comércio (RS): Proteína dá mais durabilidade para pontes de safena (24/Sep/2019)
Biblioteca FMUSP: Estudo busca maneiras de aumentar a durabilidade das pontes de safena (24/Sep/2019)
Jornal da USP online: Proteína pode aumentar a durabilidade das pontes de safena (19/Sep/2019)
Brasil CT&I: Proteína pode aumentar a durabilidade das pontes de safena (17/Sep/2019)
Espaço Ecológico no Ar: Proteína pode aumentar a durabilidade das pontes de safena e evitar novas intervenções (16/Sep/2019)
Esteta : Proteína pode aumentar a durabilidade das pontes de safena (16/Sep/2019)
Innaldo Sardinha: Proteína pode aumentar a durabilidade das pontes de safena (16/Sep/2019)
Jornal Joseense News: Proteína pode aumentar a durabilidade das pontes de safena (16/Sep/2019)
W Rádio Brasil: Proteína pode aumentar a durabilidade das pontes de safena (16/Sep/2019)
Portal da Enfermagem: Proteína pode aumentar a durabilidade das pontes de safena (16/Sep/2019)
MT HOJE: Proteína pode aumentar a durabilidade das pontes de safena (16/Sep/2019)