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Pain and quality of life in animals

Abstract

Pain is the main cause of animal suffering. It is not possible to treat pain without identifying the phenomenon, hence the importance of validated tools to guarantee a precise evaluation of pain and the qualitative and temporal effect of analgesics. Once pain is precisely evaluated, the other challenge is to search for new therapeutic strategies to provide antialgic therapy. We propose two major challenges: 1) to validate scales to assess pain and quality of life in animals and 2) to treat acute and chronic pain by pharmacological and non-conventional methods. For the former it is proposed to clinically validate the pain scales in cats (short version of the Unesp-Botucatu scale already established), horses and cattle, which have been validated experimentally in the previous project; to develop new tools to evaluate equine pain, including body language and quality of life and validate pain scales for the asinine, ovine and caprine species. For each scale, after extensive video recording work, we will construct etograms, video editing and analysis by evaluators, followed by statistical modeling validated in previous studies and with methodology considered as the only validated instrument available in the literature (MEROLA; MILLS, 2016). As pain assessment only matters when animals benefit from treatment, the second appeal is to treat pain and improve the quality of life of animals. To achieve this demand we will evaluate accurate sedative and analgesic protocols through pharmacokinetic-pharmacodynamic modeling in horses and dogs; we will advance in the study of complementary techniques (acupuncture, phytotherapy, implant of stem cells and ozone) and we will try to increase precision of the spinal anesthetic blocks guided by ultrasonography. (AU)

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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, JAQUELINE BRANDAO; ROSA, GUSTAVO DOS SANTOS; ROSSI, MARIANA CORREA; STIEVANI, FERNANDA DE CASTRO; PFEIFER, JOAO PEDRO HUBBE; TERAMOTO KRIECK, ANDRE MASSAHIRO; DE CARVALHO BOVOLATO, ANA LIVIA; FONSECA-ALVES, CARLOS EDUARDO; AMIGO BORRAS, VICENTE; GARCIA ALVES, ANA LIZ. In Vitro Biological Performance of Alginate Hydrogel Capsules for Stem Cell Delivery. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 9, AUG 27 2021. Web of Science Citations: 0.
DA ROCHA, PAULA BARRETO; DRIESSEN, BERND; MCDONNELL, SUE M.; HOPSTER, KLAUS; ZARUCCO, LAURA; GOZALO-MARCILLA, MIGUEL; HOPSTER-IVERSEN, CHARLOTTE; TRINDADE, PEDRO HENRIQUE ESTEVES; DA ROCHA, THAMIRIS KRISTINE GONZAGA; TAFFAREL, MARILDA ONGHERO; ALONSO, BRUNA BODINI; SCHAUVLIEGE, STIJN; LUNA, STELIO PACCA LOUREIRO. A critical evaluation for validation of composite and unidimensional postoperative pain scales in horses. PLoS One, v. 16, n. 8 AUG 5 2021. Web of Science Citations: 0.
OLIVEIRA, MARIA GLAUCIA CARLOS DE; PAULA, VALERIA VERAS DE; MOUTA, ANDRESSA NUNES; LIMA, ISABELLE DE OLIVEIRA; MACEDO, LUA BARBALHO DE; NUNES, TALYTA LINS; TRINDADE, PEDRO HENRIQUE ESTEVES; LUNA, STELIO PACCA LOUREIRO. Validation of the Donkey Pain Scale (DOPS) for Assessing Postoperative Pain in Donkeys. FRONTIERS IN VETERINARY SCIENCE, v. 8, JUN 11 2021. Web of Science Citations: 0.
ESTEVES TRINDADE, PEDRO HENRIQUE; TAFFAREL, MARILDA ONGHERO; LOUREIRO LUNA, STELIO PACCA. Spontaneous Behaviors of Post-Orchiectomy Pain in Horses Regardless of the Effects of Time of Day, Anesthesia, and Analgesia. ANIMALS, v. 11, n. 6 JUN 2021. Web of Science Citations: 1.
TOMACHEUSKI, RUBIA MITALLI; MONTEIRO, BEATRIZ PAGLERANI; EVANGELISTA, MARINA CAYETANO; LOUREIRO LUNA, STELIO PACCA; STEAGALL, PAULO VINICIUS. Measurement properties of pain scoring instruments in farm animals: A systematic review protocol using the COSMIN checklist. PLoS One, v. 16, n. 5 MAY 14 2021. Web of Science Citations: 0.
BELLI, MAIRA; DE OLIVEIRA, ALICE R.; DE LIMA, MAYARA T.; TRINDADE, PEDRO H. E.; STEAGALL, V, PAULO; LUNA, STELIO P. L. Clinical validation of the short and long UNESP-Botucatu scales for feline pain assessment. PeerJ, v. 9, APR 12 2021. Web of Science Citations: 0.
DE OLIVEIRA, MARIA GLAUCIA CARLOS; LUNA, STELIO P. L.; NUNES, TALYTA LINS; FIRMINO, PAULO R.; DE LIMA, AMARA GYANE A.; FERREIRA, JOSIEL; TRINDADE, PEDRO H. E.; JUNIOR, RAIMUNDO A. B.; DE PAULA, VALERIA VERAS. Post-operative pain behaviour associated with surgical castration in donkeys (Equus asinus). EQUINE VETERINARY JOURNAL, v. 53, n. 2, p. 261-266, MAR 2021. Web of Science Citations: 1.
OLIVEIRA, ALICE RODRIGUES DE; GOZALO-MARCILLA, MIGUEL; RINGER, SIMONE KATJA; SCHAUVLIEGE, STIJN; FONSECA, MARIANA WERNECK; TRINDADE, PEDRO HENRIQUE ESTEVES; PUOLI FILHO, JOSE NICOLAU PROSPERO; LUNA, STELIO PACCA LOUREIRO. Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed). FRONTIERS IN VETERINARY SCIENCE, v. 8, FEB 16 2021. Web of Science Citations: 0.
DE OLIVEIRA, ALICE RODRIGUES; GOZALO-MARCILLA, MIGUEL; RINGER, SIMONE KATJA; SCHAUVLIEGE, STIJN; FONSECA, MARIANA WERNECK; ESTEVES TRINDADE, PEDRO HENRIQUE; PROSPERO PUOLI FILHO, JOSE NICOLAU; LOUREIRO LUNA, STELIO PACCA. Development and validation of the facial scale (FaceSed) to evaluate sedation in horses. PLoS One, v. 16, n. 6 2021. Web of Science Citations: 0.
CIMA, DANIELA SANTILLI; CREDIE, LEONARDO DE FREITAS GUIMARAES ARCOVERDE; FUTEMA, FABIO; LUNA, STELIO PACCA LOUREIRO. Lumbar Epidural: Anatomical and Clinical Study in Dogs Submitted to Ovariohysterectomy. FRONTIERS IN VETERINARY SCIENCE, v. 7, NOV 3 2020. Web of Science Citations: 0.
PINHO, RENATA HADDAD; LEACH, MATTHEW C.; MINTO, BRUNO WATANABE; ROCHA, FABIANA DEL LAMA; LOUREIRO LUNA, STELIO PACCA. Postoperative pain behaviours in rabbits following orthopaedic surgery and effect of observer presence. PLoS One, v. 15, n. 10 OCT 22 2020. Web of Science Citations: 0.
SILVA, NUNO EMANUEL OLIVEIRA FIGUEIREDO; TRINDADE, PEDRO HENRIQUE ESTEVES; OLIVEIRA, ALICE RODRIGUES; TAFFAREL, MARILDA ONGHERO; MOREIRA, MARIA ALICE PIRES; DENADAI, RENAN; ROCHA, PAULA BARRETO; LUNA, STELIO PACCA LOUREIRO. Validation of the Unesp-Botucatu composite scale to assess acute postoperative abdominal pain in sheep (USAPS). PLoS One, v. 15, n. 10 OCT 14 2020. Web of Science Citations: 2.
DE OLIVEIRA, MARIA GLAUCIA CARLOS; LUNA, STELIO P. L.; NUNES, TALYTA LINS; FIRMINO, PAULO R.; DE LIMA, AMARA GYANE A.; FERREIRA, JOSIEL; TRINDADE, PEDRO H. E.; JUNIOR, RAIMUNDO A. B.; DE PAULA, VALERIA VERAS. Post-operative pain behaviour associated with surgical castration in donkeys (Equus asinus). EQUINE VETERINARY JOURNAL, v. 53, n. 2 JUL 2020. Web of Science Citations: 1.
LOUREIRO LUNA, STELIO PACCA; DE ARAUJO, ANA LUCELIA; DA NOBREGA NETO, PEDRO ISIDRO; BRONDANI, JULIANA TABARELLI; DE OLIVEIRA, FLAVIA AUGUSTA; DOS SANTOS AZEREDO, LILIANE MARINHO; TELLES, FELIPE GARCIA; ESTEVES TRINDADE, PEDRO HENRIQUE. Validation of the UNESP-Botucatu pig composite acute pain scale (UPAPS). PLoS One, v. 15, n. 6 JUN 1 2020. Web of Science Citations: 0.
FINKA, LAUREN R.; LUNA, STELIO P.; BRONDANI, JULIANA T.; TZIMIROPOULOS, YORGOS; MCDONAGH, JOHN; FARNWORTH, MARK J.; RUTA, MARCELLO; MILLS, DANIEL S. Geometric morphometrics for the study of facial expressions in non-human animals, using the domestic cat as an exemplar. SCIENTIFIC REPORTS, v. 9, JUL 8 2019. Web of Science Citations: 2.

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