Research Grants 17/17600-1 - Terpenos - BV FAPESP
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"Evaluation of the healing potential of topical formulations containing terpenes in rat skin wounds"

Abstract

The skin is essential to maintain the integrity of the body, being a differentiated protective barrier. The disruption of this system promotes the healing mechanism, physiological process that can be divided into inflammatory, proliferative and remodeling phases. Skin wounds have great importance in public health due to the possibility of some kind of physical disability, psychosocial consequences or even death. Although there are options in the market for the treatment of skin wounds, there is no "gold standard" and, in many countries, medicinal plants and molecules derived from natural products have been tested for the synthesis of new healing drugs. Therefore, the terpenes BB1524 and BC1524 will be used in the synthesis of a topic pharmaceutical formulation to evaluate the healing potential of these compounds in rat skin wounds. After the stability tests, male Wistar rats will be randomly divided into experimental groups (n = 5). The animals will be submitted to induction of the dorsal lesion 2 cm in diameter, which will receive treatment once a day and will be measured for 3, 7, 14 and 21 days. The wound area will be measured daily to verify the macroscopic reduction and clinical aspect of the wounds. After euthanasia, the wounds will be used for biochemical (anti-inflammatory and antioxidant activity), molecular (RT-qPCR), histological and immunohistochemical analyzes. In addition, systemic toxicity tests will be performed. Therefore, the molecules BB1524 and BC1524 will be used to the development of topic healing drugs and the evaluation of the healing potential of these formulations. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, MARTA H.; GUSHIKEN, LUCAS F. S.; PELLIZZON, CLAUDIA H.; MANCERA, PAULO F. A.. Mathematical modelling, parameter estimation and computational simulation for skin wound healing under Copaiferalangsdorffi treatments. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v. 199, . (14/23684-5, 11/13630-7, 17/17600-1)
GUSHIKEN, LUCAS FERNANDO SERGIO; BESERRA, FERNANDO PEREIRA; HUSSNI, MARIA FERNANDA; GONZAGA, MURILO TIRELI; RIBEIRO, VICTOR PENA; DE SOUZA, PATRICIA FERNANDA; CAMPOS, JACQUELINE COSTA LIMA; MASSARO, TAIS NADER CHRYSOSTOMO; HUSSNI, CARLOS ALBERTO; TAKAHIRA, REGINA KIOMI; et al. Beta-caryophyllene as an antioxidant, anti-inflammatory and re-epithelialization activities in a rat skin wound excision model. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2022, p. 21-pg., . (17/04138-8, 11/13630-7, 17/17600-1)
PIOTROWSKA, ANNA; BESERRA, FERNANDO PEREIRA; WIERZBICKA, JUSTYNA MARTA; NOWAK, JOANNA IRENA; ZMIJEWSKI, MICHAL ALEKSANDER. Vitamin D Enhances Anticancer Properties of Cediranib, a VEGFR Inhibitor, by Modulation of VEGFR2 Expression in Melanoma Cells. FRONTIERS IN ONCOLOGY, v. 11, . (17/17600-1)
BESERRA, FERNANDO PEREIRA; SERGIO GUSHIKEN, LUCAS FERNANDO; VIEIRA, ANA JULIA; BERGAMO, DANILO AUGUSTO; BERGAMO, PATRICIA LUISA; DE SOUZA, MARIANA OLIVEIRA; HUSSNI, CARLOS ALBERTO; TAKAHIRA, REGINA KIOMI; NOBREGA, RAFAEL HENRIQUE; MONTEIRO MARTINEZ, EMANUEL RICARDO; et al. From Inflammation to Cutaneous Repair: Topical Application of Lupeol Improves Skin Wound Healing in Rats by Modulating the Cytokine Levels, NF-kappa B, Ki-67, Growth Factor Expression, and Distribution of Collagen Fibers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 14, . (13/23340-1, 14/23247-4, 17/17600-1)
BESERRA, FERNANDO PEREIRA; VIEIRA, ANA JULIA; SERGIO GUSHIKEN, LUCAS FERNANDO; DE SOUZA, EDUARDO OLIVEIRA; HUSSNI, MARIA FERNANDA; HUSSNI, CARLOS ALBERTO; NOBREGA, RAFAEL HENRIQUE; MONTEIRO MARTINEZ, EMANUEL RICARDO; JACKSON, CHRISTOPHER JOHN; DE AZEVEDO MAIA, GABRIELA LEMOS; et al. Lupeol, a Dietary Triterpene, Enhances Wound Healing in Streptozotocin-Induced Hyperglycemic Rats with Modulatory Effects on Inflammation, Oxidative Stress, and Angiogenesis. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, . (13/23340-1, 14/23247-4, 17/17600-1)
BESERRA, FERNANDO PEREIRA; VIEIRA, ANA JULIA; SERGIO GUSHIKEN, LUCAS FERNANDO; DE SOUZA, EDUARDO OLIVEIRA; HUSSNI, MARIA FERNANDA; HUSSNI, CARLOS ALBERTO; NOBREGA, RAFAEL HENRIQUE; MONTEIRO MARTINEZ, EMANUEL RICARDO; JACKSON, CHRISTOPHER JOHN; DE AZEVEDO MAIA, GABRIELA LEMOS; et al. Lupeol, a Dietary Triterpene, Enhances Wound Healing in Streptozotocin-Induced Hyperglycemic Rats with Modulatory Effects on Inflammation, Oxidative Stress, and Angiogenesis. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2019, p. 20-pg., . (14/23247-4, 17/17600-1, 13/23340-1)
OLIVEIRA, MARTA H.; GUSHIKEN, LUCAS F. S.; PELLIZZON, CLAUDIA H.; FERREIRA, FRANCINI P.; MANCERA, PAULO F. A.. Mathematical and numerical analyses of cellular, molecular and angiogenic parameters of a rat skin wound healing model. INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, v. N/A, p. 19-pg., . (17/17600-1, 11/13630-7, 14/23684-5)

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