| Grant number: | 17/17600-1 |
| Support Opportunities: | Regular Research Grants |
| Start date: | February 01, 2018 |
| End date: | January 31, 2020 |
| Field of knowledge: | Health Sciences - Pharmacy - Pharmacognosy |
| Principal Investigator: | Claudia Helena Pellizzon |
| Grantee: | Claudia Helena Pellizzon |
| Host Institution: | Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| City of the host institution: | Botucatu |
Abstract
The skin is essential to maintain the integrity of the body, being a differentiated protective barrier. The disruption of this system promotes the healing mechanism, physiological process that can be divided into inflammatory, proliferative and remodeling phases. Skin wounds have great importance in public health due to the possibility of some kind of physical disability, psychosocial consequences or even death. Although there are options in the market for the treatment of skin wounds, there is no "gold standard" and, in many countries, medicinal plants and molecules derived from natural products have been tested for the synthesis of new healing drugs. Therefore, the terpenes BB1524 and BC1524 will be used in the synthesis of a topic pharmaceutical formulation to evaluate the healing potential of these compounds in rat skin wounds. After the stability tests, male Wistar rats will be randomly divided into experimental groups (n = 5). The animals will be submitted to induction of the dorsal lesion 2 cm in diameter, which will receive treatment once a day and will be measured for 3, 7, 14 and 21 days. The wound area will be measured daily to verify the macroscopic reduction and clinical aspect of the wounds. After euthanasia, the wounds will be used for biochemical (anti-inflammatory and antioxidant activity), molecular (RT-qPCR), histological and immunohistochemical analyzes. In addition, systemic toxicity tests will be performed. Therefore, the molecules BB1524 and BC1524 will be used to the development of topic healing drugs and the evaluation of the healing potential of these formulations. (AU)
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