Effect of medication, dual tasking and asymmetry on the cortical brain activity during gait in older people with Parkinson's disease

• Grant number: 17/19516-8
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2018
• End date: November 30, 2020
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Fabio Augusto Barbieri
• Grantee: Fabio Augusto Barbieri
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• City of the host institution: Bauru
• Associated researchers: Fernanda Assis Paes Habechian Zamunér ; Manuel María Montero-Odasso ; Paula Fávaro Polastri Zago ; Sérgio Tosi Rodrigues

Abstract

The Parkinson's disease (PD) seems to reduce the cortical activity, which impairs the motor planning and the adjustments for a precise locomotion. However, the mechanisms of the cortical activities associated to locomotion disorders in PD, especially related to the effects of dopaminergic medication, the complexity of cognitive dual tasking and the asymmetry in the disease, are not well understood. Therefore, the purpose of this study is to analyze the cortical activity behavior during gait in older adults with PD, considering the acute effect of dopaminergic medication state, the complexity of cognitive dual tasking and the PD asymmetry. To answer the questions of the project, three studies will be developed. In the first study, older adults with PD will walk with and without obstacle avoidance in an "off" state of dopaminergic medication and every 15 minutes after having taken their typically prescribed dose of levodopa until 3 hours after medication taken. This study will investigate the temporal effect of the morning levodopa on cortical activity behavior and spatial-temporal and muscular parameters of walking and the duration of this effect on the parameters analyzed. In the second study, older adults with PD and neurologically healthy older individuals will perform a series of walking with cognitive dual task conditions, which will have different levels of the complexity. We will determine the complexity level of the dual cognitive task that will affect cortical activity behavior and motor parameters of walking in both groups. In the third study, older adults with PD and neurologically healthy older individuals will perform obstacle circumvention during walking for both sides. We will investigate the cortical activity behavior when an asymmetrical task is performed and analyze the relation to cortical activity behavior and motor and visual parameters during gait. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORRADINI, JULIA R.; SILVEIRA-CIOLA, ALINE P.; PEREIRA, VINICIUS A. I.; KURODA, MARINA H.; FARIA, MURILO H.; SIMIELI, LUCAS; TAVARES, JOAO MANUEL R. S.; BARBIERI, FABIO A.. Dual tasking reduces gait asymmetry of trajectory deviation during obstacle circumvention in people with Parkinson's disease. HUMAN MOVEMENT SCIENCE, v. 83, p. 10-pg., 2022-06-01. (17/19516-8, 20/01250-4, 15/15928-4)

AMBIKE, SATYAJIT; PENEDO, TIAGO; KULKARNI, ASHWINI; SANTINELLI, FELIPE BALISTIERI; BARBIERI, FABIO A.. Step length synergy while crossing obstacles is weaker in patients with Parkinson's disease. GAIT & POSTURE, v. 84, p. 340-345, FEB 2021. (17/19516-8, 18/03448-6)

ARAUJO-SILVA, FABIANA; SANTINELLI, FELIPE B.; IMAIZUMI, LUIS FELIPE I.; SILVEIRA, ALINE P. B.; VIEIRA, LUIZ H. P.; ALCOCK, LISA; BARBIERI, FABIO A.. Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease. Brain Research, v. 1775, JAN 15 2022. (17/19516-8, 18/03448-6)

FERREIRA, MARTA ISABEL A. S. N.; BARBIERI, FABIO AUGUSTO; MORENO, VINICIUS CHRISTIANINI; PENEDO, TIAGO; TAVARES, JOAO MANUEL R. S.. Machine learning models for Parkinson's disease detection and stage classification based on spatial-temporal gait parameters. GAIT & POSTURE, v. 98, p. 7-pg., 2022-10-01. (17/19516-8, 14/20549-0, 20/01250-4)

PENEDO, TIAGO; KALVA-FILHO, CARLOS AUGUSTO; CURSIOL, JONATAS AUGUSTO; FARIA, MURILO HENRIQUE; COELHO, DANIEL BOARI; BARBIERI, FABIO AUGUSTO. Spatial-temporal parameters during unobstructed walking in people with Parkinson's disease and healthy older people: a public data set. FRONTIERS IN AGING NEUROSCIENCE, v. 16, p. 7-pg., 2024-03-28. (20/01250-4, 22/16112-1, 18/03448-6, 14/20549-0, 17/19516-8, 19/24752-8, 15/15928-4, 22/02971-2, 12/24040-9, 21/09690-6)

COSTA, ELISA DE CARVALHO; SANTINELLI, FELIPE BALISTIERI; MORETTO, GABRIEL FELIPE; FIGUEIREDO, CAIQUE; MORANO, ANA ELISA VON AH; BARELA, JOSE ANGELO; BARBIERI, FABIO AUGUSTO. A multiple domain postural control assessment in people with Parkinson?s disease: traditional, non-linear, and rambling and trembling trajectories analysis. GAIT & POSTURE, v. 97, p. 7-pg., 2022-08-03. (17/19516-8)

PIRES, RAFAEL GONCALVES; PEREIRA, CLAYTON REGINALDO; PENEDO, TIAGO; PAPA, JOAO PAULO; RODER, MATEUS; BARBIERI, FABIO AUGUSTO. Assessing Levodopa Effectiveness in Parkison's Disease During Gait Using Electroencephalogram and Machine Learning. 2024 31ST INTERNATIONAL CONFERENCE ON SYSTEMS, SIGNALS AND IMAGE PROCESSING, IWSSIP 2024, v. N/A, p. 5-pg., 2024-01-01. (18/03448-6, 17/19516-8, 22/02971-2, 23/14427-8, 19/07665-4, 13/07375-0)

VIEIRA, LUIZ H. PALUCCI; CARLING, CHRISTOPHER; DA SILVA, JOAO PEDRO; SANTINELLI, FELIPE B.; POLASTRI, PAULA F.; SANTIAGO, PAULO R. P.; BARBIERI, FABIO A.. Modelling the relationships between EEG signals, movement kinematics and outcome in soccer kicking. COGNITIVE NEURODYNAMIC, v. N/A, p. 19-pg., 2022-02-25. (18/02965-7, 20/04282-4, 17/19516-8)