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Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector

Grant number: 17/04138-8
Support type:Research Projects - Thematic Grants
Duration: March 01, 2018 - February 28, 2023
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Jairo Kenupp Bastos
Grantee:Jairo Kenupp Bastos
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
José Maurício Sforcin ; Sergio Ricardo Ambrosio
Assoc. researchers:Antonio Cardozo dos Santos ; Antônio Eduardo Miller Crotti ; Ariane Leite Rozza ; Carlos Henrique Gomes Martins ; Claudia Helena Pellizzon ; Denise Crispim Tavares Barbosa ; José Maurício Sforcin ; Juliana Issa Hori ; Lizandra Guidi Magalhães ; Luis Alexandre Pedro de Freitas ; Luiz Alberto Beraldo de Moraes ; Márcio Luís Andrade e Silva ; Niege Araçari Jacometti Cardoso Furtado ; Priscyla Daniely Marcato Gaspari ; Raquel Alves dos Santos ; Renato Luis Tame Parreira ; Ricardo Andrade Furtado ; Rodrigo Cassio Sola Veneziani ; Vanessa Leiria Campo ; Vera Lúcia Lanchote ; Vladimir Constantino Gomes Heleno ; Wilson Roberto Cunha
Associated grant(s):18/05080-6 - Multi-user equipment approved in grant 2017/04138-8 for high pressure semipreparative chromatographic system model LC-20AR, AP.EMU
Associated scholarship(s):20/14639-7 - Immunomodulatory action of propolis on monocytes of pregnant women with preeclampsia and on human umbilical vein endothelial cells (HUVEC), BP.PD
22/00659-1 - In vitro evaluation of the metabolism of the major compounds of Araucaria sp brown propolis, BP.PD
21/11658-3 - Toxicological evaluation of brown propolis in in vitro and in vivo test systems, BP.IC
+ associated scholarships 21/10516-0 - Evaluation of the healing potential of nanoemulsion containing green propolis extract in the treatment of wounds in hyperglycemic rats infected with methicillin-resistant Staphylococcus aureus, BP.IC
21/12338-2 - Analysis of the cellular effects of the standardized red propolis extract on HeLa and SiHa Cervix Cancer cell lines, BP.IC
21/01411-0 - Chemical study of the Caatinga propolis produced by Apis mellifera and re-isolation of red propolis compounds to perform biological tests and develop analytical methods., BP.PD
21/03788-4 - Pharmacokinetics assessments of red propolis prenylated benzophenones, BP.DR
21/01258-8 - Characterization of fibroblasts and endothelial cells activity on wound healing in rats treated topically with red Brazilian propolis, BP.IC
20/12161-2 - Red propolis: development and validation of an analytical method by liquid chromatography coupled to mass spectrometry, BP.MS
19/25979-6 - Evaluation of anti-inflammatory potential of kaempferide in paw edema and toxicological profile, BP.IC
19/14496-4 - Determination of the potential of solid lipid nanoparticles containing green propolis rich in artepelin C in vitro and in the topical therapy of wounds diabetic rats infected with methicillin-resistant Staphylococcus aureus, BP.PD
19/21743-8 - Evaluation of hiperalgesic, anti-inflammatory and toxicological activies of red propolis, BP.IC
19/11700-0 - Evaluation of the antimicrobial and antiparasitic activities of Artepillin C and its derivatives and study of their gas-phase fragmentation reactions using tandem mass spectrometry, BP.DR
19/01697-1 - Phytochemical study and cytotoxic evaluation of the hexanic fraction and isolated compounds from red propolis produced by Apis mellifera L., BP.IC
17/26252-7 - No clinical toxicology studies of red propolis and its botanical source Dalbergia ecastophyllum (L.) Taub., BP.DR
18/25770-7 - In vitro, in vivo and in silico studies of the antineoplastic activity of guttiferone e in melanoma, BP.MS
18/25010-2 - Isolation and identification of green and brown propolis constituents., BP.PD
18/16172-9 - Development and characterization of nanostructured lipid carriers using Brazilian red propolis in photoprotective formulations, BP.MS
18/25108-2 - Study of antibacterial potential and mixed antibiofilm formation of green propolis against multidrug resistant strains, BP.IC
17/01618-9 - Study of the potential hypocholesterolemic and antioxidant properties of green propolis and the fraction rich in Artepillin C in vitro and in a diet-induced hypercholesterolemia model in guinea pigs (Cavia porcellus), BP.PD
17/08386-6 - Phytochemical study, development of analytical method and biological evaluation of brown propolis produced by Apis mellifera from Morus Alba, BP.DR
18/17402-8 - Effects of the association cisplatin/green propolis ethanolic extract on A549 cell line: a cell death analysis, BP.IC
18/13700-4 - HSCCC method development for the isolation and identification of red propolis constituents, BP.PD
18/00979-0 - Analysis of the anti-inflammatory potential of green propolis against formalin-induced nociception, BP.IC
18/09601-0 - Phytochemical study and antimicrobial evaluation of brown propolis produced by Apis mellifera L. from Eucalyptus spp, BP.IC
18/02370-3 - Evaluation of the quimiopreventive potential of the Brazilian propolis red HYDROALCOOLIC extract, BP.MS
18/03476-0 - Biotransformations of baccharin from green propolis using filamentous fungi and bacteria from the intestinal microbiota, BP.MS
18/06675-3 - In vitro and in vivo toxicogenic study of the hydroalcoholic extract of red propolis in mammalian cells, BP.IC - associated scholarships

Abstract

The Brazilian propolis produced by Apis mellifera called green, brown and red have great economic importance, due to their biological activities and export to several countries, such as Japan and China, and production of approximately 200 tons per year. The main botanical origins of Brazilian propolis are: Baccharis dracunculifolia for green propolis; Araucaria sp, Eucalyptus sp and others for brown propolis; and Dalbergia ecastophyllum for the red propolis. In 2005, ANVISA published a technical note on the registration of products containing propolis, as well as the RDC no. 24/2011 authorizing the registration of propolis-based medicines. However, to date none medicine has been registered with ANVISA. There are many gaps to be filled, since ANVISA demands the execution of chemical, analytical, pharmacological and technological studies to guarantee safety, efficacy and quality in the development of new medicines. Thus, it is proposed to carry out complementary steps in phytochemical studies to obtain standardized extracts and compounds to be used in the development of analytical methods; in obtaining semi-synthetic derivatives; in stability and degradation studies; in bioaccessibility, biotransformation, pharmacokinetic and pharmacodynamic studies; in in silico studies to determine chemical structure-activity relationship and docking analyses; in the development of pharmaceutical formulations; in both in vitro and in vivo toxicological studies; in studies of genotoxicity and mutagenicity; in anti-inflammatory, immunomodulatory, antimicrobial, antiparasitic, antiproliferative, healing and gastroprotective assays, among others. The ultimate goal of this proposal is to add value to the Brazilian beekeeping sector. (AU)

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Scientific publications (30)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WATANABE, AKIO; DE ALMEIDA, MARILIA OLIVEIRA; DEGUCHI, YUSUKE; KOZUKA, RYUZO; ARRUDA, CAROLINE; BERRETTA, ANDRESA APARECIDA; BASTOS, JAIRO KENUPP; WOO, JE-TAE; YONEZAWA, TAKAYUKI. Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 13, . (17/04138-8)
RIBEIRO, VICTOR PENA; ARRUDA, CAROLINE; ALDANA-MEJIA, JENNYFER ANDREA; BASTOS, JAIRO KENUPP; TRIPATHI, SIDDHARTH K.; KHAN, I, SHABANA; KHAN, IKHLAS A.; ALI, ZULFIQAR. Phytochemical, Antiplasmodial, Cytotoxic and Antimicrobial Evaluation of a Southeast Brazilian Brown Propolis Produced by Apis mellifera Bees. CHEMISTRY & BIODIVERSITY, v. 18, n. 9, . (17/04138-8, 19/12978-1)
A. DE L. PAULA, LUCAS; SANTOS, MARIO F. C.; PAGOTTI, MARIANA C.; FALEIROS, RENATA; RAMOS, HENRIQUE P.; VENEZIANI, RODRIGO C. S.; BASTOS, JAIRO K.; CAFFREY, CONOR R.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G.. Uncovering Biological Application of Brazilian Green Propolis: A Phenotypic Screening againstSchistosoma mansoni. CHEMISTRY & BIODIVERSITY, v. 17, n. 9, . (17/04138-8, 18/50011-2)
BOEING, THAISE; COSTA, PHILIPE; VENZON, LARISSA; MEURER, MARIANE; BOLDA MARIANO, LUISA NATHALIA; SANTOS FRANCA, TAUANI CAROLINE; GOUVEIA, LUANA; DE BASSI, ANNY CAROLINE; STEIMBACH, VIVIANE; DE SOUZA, PRISCILA; et al. Gastric healing effect ofp-coumaric acid isolated fromBaccharis dracunculifoliaDC on animal model. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 394, n. 1, . (17/04138-8)
COSTA, PHILIPE; ALMEIDA, MARILIA O.; LEMOS, MARIVANE; ARRUDA, CAROLINE; CASOTI, ROSANA; SOMENSI, LINCON BORDIGNON; BOEING, THAISE; MARIOTT, MARIHA; DE ANDRADE FONSECA DA SILVA, RITA DE CASSIA MELO VILHENA; STEIN, BRUNA DE PAOLI; et al. Artepillin C, drupanin, aromadendrin-4'-O-methyl-ether and kaempferide from Brazilian green propolis promote gastroprotective action by diversified mode of action. Journal of Ethnopharmacology, v. 226, p. 82-89, . (17/04138-8)
BOLDA MARIANO, LUISA NATHALIA; ARRUDA, CAROLINE; SOMENSI, LINCON BORDIGNON; MICHELS COSTA, ANA PAULA; PERONDI, EDUARDO GNOATTO; BOEING, THAISE; MARIOTT, MARIHA; DE ANDRADE FONSECA DA SILVA, RITA DE CASSIA MELO VILHENA; DE SOUZA, PRISCILA; BASTOS, JAIRO KENUPP; et al. Brazilian green propolis hydroalcoholic extract reduces colon damages caused by dextran sulfate sodium-induced colitis in mice. INFLAMMOPHARMACOLOGY, v. 26, n. 5, p. 1283-1292, . (17/04138-8)
PIOTROWSKI, MAURICIO J.; NAGURNIAK, GLAUCIO R.; DA SILVA, EDER H.; PARREIRA, RENATO L. T.. Bare versus protected tetrairidium clusters by density functional theory. Physical Chemistry Chemical Physics, v. 20, n. 46, p. 29480-29492, . (17/04138-8, 11/07623-8)
BOTTEON, C. E. A.; SILVA, L. B.; CCANA-CCAPATINTA, G. V.; SILVA, T. S.; AMBROSIO, S. R.; VENEZIANI, R. C. S.; BASTOS, J. K.; MARCATO, P. D.. Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities. SCIENTIFIC REPORTS, v. 11, n. 1, . (18/13465-5, 14/50928-2, 17/04138-8)
RODRIGUES, DEBORA MUNHOZ; PORTAPILLA, GISELE BULHOES; SILVA, GUILHERME MARTINS; DUARTE, ANDRESSA; ROTTA, CRISTIANA GONCALEZ; DA SILVA, CARLOS HENRIQUE TOMICH DE PAULA; DE ALBUQUERQUE, SERGIO; BASTOS, JAIRO KENUPP; CAMPO, VANESSA LEIRIA. Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. Bioorganic & Medicinal Chemistry, v. 47, . (17/04138-8)
FERREIRA, JULIANA C.; REIS, MOUZARLLEM B.; COELHO, GIOVANNA D. P.; GASTALDELLO, GABRIEL H.; PETI, ANA PAULA F.; RODRIGUES, DEBORA M.; BASTOS, JAIRO K.; CAMPO, VANESSA L.; SORGI, CARLOS A.; FACCIOLI, LUCIA H.; et al. Baccharin and p-coumaric acid from green propolis mitigate inflammation by modulating the production of cytokines and eicosanoikds. Journal of Ethnopharmacology, v. 278, . (19/21938-3, 17/04138-8)
CCANA-CCAPATINTA, GARI VIDAL; ALDANA MEJIA, JENNYFER ANDREA; TANIMOTO, MATHEUS HIKARU; GROPPO, MILTON; ANDRADE SARMENTO DE CARVALHO, JEAN CARLOS; BASTOS, JAIRO KENUPP. Dalbergia ecastaphyllum (L.) Taub. and Symphonia globulifera L.f.: The Botanical Sources of Isoflavonoids and Benzophenones in Brazilian Red Propolis. Molecules, v. 25, n. 9, . (17/04138-8, 17/26252-7, 18/13700-4, 19/01697-1)
BESERRA, FERNANDO PEREIRA; GUSHIKEN, LUCAS FERNANDO SERGIO; HUSSNI, MARIA FERNANDA; RIBEIRO, VICTOR PENA; BONAMIN, FLAVIA; JACKSON, CHRISTOPHER JOHN; PELLIZZON, CLAUDIA HELENA; BASTOS, JAIRO KENUPP. Artepillin C as an outstanding phenolic compound of Brazilian green propolis for disease treatment: A review on pharmacological aspects. Phytotherapy Research, v. 35, n. 5, p. 2274-2286, . (17/04138-8)
MIGLIORE, LETIZIA J.; CCANA-CCAPATINTA, V, GARI; CURLETTI, GIANFRANCO; CASARI, SONIA A.; BIFFI, GABRIEL; MEJIA, JENNYFER A. A.; CARVALHO, JEAN C. A. S.; BASTOS, JAIRO K.. new species of jewel beetle (Coleoptera, Buprestidae, Agrilus) triggers the production of the Brazilian red propoli. NATURWISSENSCHAFTEN, v. 109, n. 2, . (17/04138-8, 18/13700-4, 17/26252-7)
ARRUDA, CAROLINE; RIBEIRO, VICTOR PENA; MEJIA, JENNYFER ANDREA ALDANA; ALMEIDA, MARILIA OLIVEIRA; GOULART, MIRIAN OLIVEIRA; CANDIDO, ANA CAROLINA BOLELA BOVO; DOS SANTOS, RAQUEL ALVES; MAGALHAES, LIZANDRA GUIDI; MARTINS, CARLOS HENRIQUE GOMES; BASTOS, JAIRO KENUPP. Green Propolis: Cytotoxic and Leishmanicidal Activities of Artepillin C,p-Coumaric Acid, and Their Degradation Products. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 30, n. 2, p. 169-176, . (17/04138-8)
RODRIGUES, DEBORA MUNHOZ; DE SOUZA, MARCELO CLARO; ARRUDA, CAROLINE; PEREIRA, RODRIGO AUGUSTO SANTINELO; BASTOS, JAIRO KENUPP. The Role of Baccharis dracunculifolia and its Chemical Profile on Green Propolis Production by Apis mellifera. Journal of Chemical Ecology, v. 46, n. 2, . (17/04138-8, 15/04148-8)
ARRUDA, CAROLINE; RIBEIRO, VICTOR PENA; ALMEIDA, MARILIA OLIVEIRA; ALDANA MEJIA, JENNYFER ANDREA; CASOTI, ROSANA; BASTOS, JAIRO KENUPP. Effect of light, oxygen and temperature on the stability of artepillin C and p-coumaric acid from Brazilian green propolis. Journal of Pharmaceutical and Biomedical Analysis, v. 178, . (17/04138-8)
SILVA, THAYNA DE SOUZA; SILVA, JULIA M. B.; BRAUN, GLAUCIA H.; MEJIA, JENNYFER A. A.; CCAPATINTA, GARI V. C.; CONCEICAO SANTOS, MARIO FERREIRA; TANIMOTO, MATHEUS H.; BASTOS, JAIRO K.; PARREIRA, RENATO L. T.; ORENHA, RENATO P.; et al. Green and Red Brazilian Propolis: Antimicrobial Potential and Anti-Virulence against ATCC and Clinically Isolated Multidrug-Resistant Bacteria. CHEMISTRY & BIODIVERSITY, v. 18, n. 8, . (18/13700-4, 17/04138-8, 19/01697-1, 18/05080-6)
CARDOSO, ELIZA DE OLIVEIRA; SANTIAGO, KARINA BASSO; CONTI, BRUNO JOSE; CONTE, FERNANDA LOPES; TASCA, KAREN INGRID; ROMAGNOLI, GRAZIELA GORETE; GOLIM, MARJORIE DE ASSIS; RAINHO, CLAUDIA APARECIDA; BASTOS, JAIRO KENUPP; SFORCIN, JOSE MAURICIO. razilian green propolis: A novel tool to improve the cytotoxic and immunomodulatory action of docetaxel on MCF-7 breast cancer cells and on women monocyt. Phytotherapy Research, v. 36, n. 1, . (16/09986-4, 17/04138-8)
PIVETTA, THAIS P.; BOTTEON, CAROLINE E. A.; RIBEIRO, PAULO A.; MARCATO, PRISCYLA D.; RAPOSO, MARIA. Nanoparticle Systems for Cancer Phototherapy: An Overview. NANOMATERIALS, v. 11, n. 11, . (17/04138-8, 18/13465-5)
MARTINS, NUBIA SABRINA; DE CAMPOS FRAGA-SILVA, THAIS FERNANDA; CORREA, GISELI FURLAN; BOKO, MEDETON MAHOUSSI MICHAEL; RAMALHO, LEANDRA NAIRA ZAMBELLI; RODRIGUES, DEBORA MUNHOZ; HORI, JULIANA ISSA; COSTA, DIEGO LUIS; BASTOS, JAIRO KENUPP; BONATO, VANIA LUIZA DEPERON. Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells. PHARMACEUTICS, v. 13, n. 11, . (19/09881-6, 19/23446-0, 19/18793-3, 17/04138-8)
NAGURNIAK, GLAUCIO REGIS; TEIXEIRA PERACA, CARINA DE SOUZA; ORENHA, RENATO PEREIRA; TAME PARREIRA, RENATO LUIS; PIOTROWSKI, MAURICIO JEOMAR. Double-bond elucidation for arsagermene with a tricoordinate germanium center: a theoretical survey. NEW JOURNAL OF CHEMISTRY, v. 43, n. 39, p. 15681-15690, . (11/07623-8, 17/04138-8)
ALDANA-MEJIA, JENNYFER A.; CCANA-CCAPATINTA, V, GARI; SQUARISI, IARA S.; NASCIMENTO, SAMUEL; TANIMOTO, MATHEUS H.; RIBEIRO, VICTOR P.; ARRUDA, CAROLINE; NICOLELLA, HELOIZA; ESPERANDIM, TABATA; RIBEIRO, ARTHUR B.; et al. onclinical Toxicological Studies of Brazilian Red Propolis and Its Primary Botanical Source Dalbergia ecastaphyllu. Chemical Research in Toxicology, v. 34, n. 4, p. 1024-1033, . (17/04138-8, 17/26252-7)
PAULA, LUCAS A. DE L.; SANTOS, MARIO F. C.; PAGOTTI, MARIANA C.; VENEZIANI, RODRIGO C. S.; BASTOS, JAIRO K.; CAFFREY, CONOR R.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G.. razilian green propolis reduces worm burden and hepatic granuloma formation in a Schistosoma mansoni experimental murine mode. Parasitology Research, v. 121, n. 2, p. 775-780, . (18/50011-2, 17/04138-8, 18/25010-2, 18/05080-6)
RIBEIRO, VICTOR PENA; ARRUDA, CAROLINE; MEJIA, JENNYFER ANDREA ALDANA; CANDIDO, ANA CAROLINA BOLELA BOVO; DOS SANTOS, RAQUEL ALVES; MAGALHAES, LIZANDRA GUIDI; BASTOS, JAIRO KENUPP. Brazilian southeast brown propolis: gas chromatography method development for its volatile oil analysis, its antimicrobial and leishmanicidal activities evaluation. Phytochemical Analysis, v. 32, n. 3, . (17/04138-8, 17/08386-6)
RIBEIRO, VICTOR PENA; SIMARO, GUILHERME VENANCIO; MEJIA, JENNYFER ANDREA ALDANA; ARRUDA, CAROLINE; BASTOS, JAIRO KENUPP. Anti-inflammatory and Antinociceptive Activities of the Hydroalcoholic Extract and the Volatile Fraction of Southeastern Brazilian Brown Propolis. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 31, n. 1, p. 59-66, . (17/08386-6, 17/04138-8)
SANTOS, MARIO FERREIRA CONCEICAO; OLIVEIRA, LARISSA COSTA; RIBEIRO, VICTOR PENA; SOARES, MARISI GOMES; MORAE, GABRIEL DE OLIVEIRA ISAC; SARTORI, ALAN GIOVANINI DE OLIVEIRA; ROSALEN, PEDRO LUIZ; BASTOS, JAIRO KENUPP; DE ALENCAR, SEVERINO MATIAS; VENEZIANI, RODRIGO CASSIO SOLA; et al. Isolation of diterpenes from Araucaria sp Brazilian brown propolis and development of a validated high-performance liquid chromatography method for its analysis. JOURNAL OF SEPARATION SCIENCE, v. 44, n. 16, . (17/04138-8, 18/25010-2, 18/05080-6)
GUSHIKEN, LUCAS FERNANDO SERGIO; BESERRA, FERNANDO PEREIRA; BASTOS, JAIRO KENUPP; JACKSON, CHRISTOPHER JOHN; PELLIZZON, CLAUDIA HELENA. Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies. LIFE-BASEL, v. 11, n. 7, . (17/04138-8)
DE L. PAULA, LUCAS A.; CANDIDO, ANA C. B. B.; SANTOS, MARIO F. C.; CAFFREY, CONOR R.; BASTOS, JAIRO K.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G.. Antiparasitic Properties of Propolis Extracts and Their Compounds. CHEMISTRY & BIODIVERSITY, v. 18, n. 9, . (17/04138-8, 18/50011-2)
DE OLIVEIRA SARTORI, ALAN GIOVANINI; SPADA, FERNANDA PAPA; RIBEIRO, VICTOR PENA; ROSALEN, PEDRO LUIZ; IKEGAKI, MASAHARU; BASTOS, JAIRO KENUPP; DE ALENCAR, SEVERINO MATIAS. An insight into the botanical origins of propolis from permanent preservation and reforestation areas of southern Brazil. SCIENTIFIC REPORTS, v. 11, n. 1, . (17/04138-8, 19/11248-0)
BOEING, THAISE; MEJIA, JENNYFER ANDREA ALDANA; CCANA-CCAPATINTA, GARI VIDAL; MARIOTT, MARIH; DA SILVA, RITA DE CASSIA MELO VILHENA DE ANDRADE FONSECA; DE SOUZA, PRISCILA; MARIANO, LUISA NATHALIA BOLDA; OLIVEIRA, GRAZIELA REGINA; DA ROCHA, ISABELLE MORAES; DA COSTA, GABRIELA ALTINI; et al. The gastroprotective effect of red propolis extract from Northeastern Brazil and the role of its isolated compounds. Journal of Ethnopharmacology, v. 267, . (17/04138-8)

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