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Amniotic progenitor cells and therapeutics potention

Grant number: 17/21266-0
Support type:Regular Research Grants
Duration: April 01, 2018 - June 30, 2020
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Carlos Eduardo Ambrósio
Grantee:Carlos Eduardo Ambrósio
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Assoc. researchers:Daniele dos Santos Martins ; Silvio Henrique de Freitas ; Valéria Maria Lara Carregaro

Abstract

In recent decades, veterinary medicine and innovative therapies have grown exponentially using new therapeutic tools, either with stem cell use or genetics editions. In this project we focus on studies in undifferentiated cells with high proliferation capacity and fetal characteristics, of the origin of fetal membranes, such as amnion. The amniotic membrane discarded in veterinary medicine is considered an excellent cell source for obtaining stem cells, as it does not require invasive procedures for acquisition and offers a significant amount for preclinical studies. Currently, in veterinary medicine, there is little information related to the immunomodulatory properties of amniotic membrane. Thus, it becomes relevant that these cells are characterized by their potential, immunomodulatory role and secretory components, such as extracellular vesicles. In addition, therapeutic medicine is constantly advancing, and the study of organ development and its molecular functions are in full progression. Another point of study will focus on cell-cell communication through the transport of epigenetic components (microRNA and mRNA) performed by the extracellular vesicles of the amnion, which are secreted by different cell types, the exosomes. We have worked on the creation of an animal source stem cell bank, which could assist different research centers in molecular and clinical understanding and integrate this information. This is one of the proposals in this project, to provide a bank of mesenchymal stem cells from the placental membranes of different animal sources in order to guarantee the safety and quality for the use of these cell lines, establishing free contamination protocols, aiming at the standardization and validation of procedures and analytical techniques involved in the manufacture of cellular therapy products for veterinary use representing an important advance. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PINHEIRO, ALESSANDRA DE OLIVEIRA; LARA, VALERIA M.; SOUZA, ALINE F.; CASALS, JULIANA B.; BRESSAN, FABIANA F.; FANTINATO NETO, PAULO; OLIVEIRA, VANESSA C.; MARTINS, DANIELE S.; AMBROSIO, CARLOS E. Characterization and Immunomodulation of Canine Amniotic Membrane Stem Cells. STEM CELLS AND CLONING-ADVANCES AND APPLICATIONS, v. 13, p. 43-55, 2020. Web of Science Citations: 0.
AMBROSIO, CARLOS EDUARDO; ORLANDIN, JESSICA RODRIGUES; OLIVEIRA, VANESSA CRISTINA; BRANCO MOTTA, LINA CASTELO; FERREIRA PINTO, PRISCILLA AVELINO; PEREIRA, VITORIA MATTOS; PADOVEZE, LETICIA RIBEIRO; KARAM, RAFAEL GARCIA; PINHEIRO, ALESSANDRA DE OLIVEIRA. Potential application of aminiotic stem cells in veterinary medicine. ANIMAL REPRODUCTION, v. 16, n. 1, p. 24-30, JAN-MAR 2019. Web of Science Citations: 0.
MANCANARES, CELINA A. F.; DE OLIVEIRA, VANESSA CRISTINA; OLIVEIRA, LILIAN J.; MIGLINO, MARIA A.; MEIRELLES, FLAVIO VIEIRA; AMBROSIO, CARLOS E. Morphological and Molecular Analysis of In Vitro Tubular Structures from Bovine Yolk Sac-Derived MSCs. STEM CELLS INTERNATIONAL, 2019. Web of Science Citations: 0.
ZOMER, HELENA DEBIAZI; ROBALLO, KELLY C. S.; LESSA, THAIS BORGES; BRESSAN, FABIANA FERNANDES; GONCALVES, NATALIA NARDELI; MEIRELLES, FLAVIO VIEIRA; TRENTIN, ANDREA GONCALVES; AMBROSIO, CARLOS EDUARDO. Distinct features of rabbit and human adipose-derived mesenchymal stem cells: implications for biotechnology and translational research. STEM CELLS AND CLONING-ADVANCES AND APPLICATIONS, v. 11, p. 43-54, 2018. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.