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Microelectronic platforms for electrochemical, piezoelectric and FETs biosensors

Grant number: 17/24201-6
Support type:Regular Research Grants
Duration: April 01, 2018 - March 31, 2020
Field of knowledge:Engineering - Electrical Engineering
Principal Investigator:Marcelo Mulato
Grantee:Marcelo Mulato
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Marina Ribeiro Batistuti ; Pedro Miguel de Lemos Correia Estrela
Associated grant(s):18/22155-0 - Dendritic cell interactions for early dengue virus detection and disease understanding, AP.R

Abstract

The development of biosensors has been continuously growing every year due tothe possibility of fast and accurate detection of a wide variety of target moleculesor biomarkers, especially in the medical and diagnostic areas. Miniaturization ofthese devices will lead to less invasive testing and reduction of sample volume. Thisproject aims at the study and development of microelectronic biosensors mainlyusing FTO, ITO and gold surfaces modified with polymers, carbon nanostructuresand self-assembled monolayers. Modifications with polymers such as polyanilineallow the immobilization of enzymes and antibodies to detect glucose, lactateand pyruvate. Carbon nanostructures such as graphene and nanotubes allow theimmobilization of enzymes and oligonucleotides. And the gold surfaces can bemodified with polymers as well as with self-assembled monolayers allowing differentmethods of oligonucleotide immobilization, including microRNA and aptamers.The development and optimization of these different platforms, as well as thedetection of the analytes of interest, are based on potentiometric techniques (such aselectrochemical impedance spectroscopy, and extended-gate fieldeffect transistors),piezoelectric (quartz crystal microbalance) and optical methods (through reflectancechange of the polymers after detection). As an innovation, this project startsthe multiplex platform to detect different biomarkers at the same time. Thus, itis expected that, in the end, a further step will be taken in the development ofmicroelectronic biosensors aiming at large-scale medical application, low cost andlow limits of detection. (AU)