Advanced search
Start date
Betweenand

TISSUE ENGINEERING OF BLOOD VESSELS: MODEL IN RABBITS - IN VITRO

Abstract

Cardiovascular disease is the leading cause of death in Western populations. The Peripheral Arterial Disease is part of this group of diseases and is present in 5% of the population. In about 20 to 30% of symptomatic cases, evolution occurs for lower limb amputation. Recent research involving stem cells and cell engineering point to a promising future based on replacement therapy and regenerative tissue. Cell therapy is a branch of regenerative medicine and therapeutics and consists of three strands: conductive, which refers to the re-establishment of autonomous cells by external stimuli; inductive, in which growth factors are added to the cell so that it regenerates and the third part is represented by the stem cells, which are used for tissue regeneration therapy. The challenge of this study focuses on the improvement of tissue engineering of blood vessels from animal models (rabbits) in vitro. The technique will be to build and test a new vascular conduit produced from differentiated stem cells. These cells will be induced to differentiate into endothelial tissue after being attached to a decellularized scaffold vena cava, in vitro. The perspective is use this model in the animal in vivo and thereby extended the possibilities of treatment applied in human vascular grafts (bypass), for specific cases where the conventional techniques are not applicable. Thus, it is hoped to contribute for the development of tissue engineering of blood vessels.Keywords: Peripheral Arterial Disease, Stem Cells, Cell Therapy, Endothelium. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)