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Development of Polymeric Carriers for Controlled Release Systems Using alfa-aryl-N-aryl-Nitrones

Grant number: 17/23405-7
Support type:Regular Research Grants
Duration: October 01, 2018 - December 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Márcio Luiz dos Santos
Grantee:Márcio Luiz dos Santos
Home Institution: Anhanguera Educacional S/A (AESA). São Bernardo do Campo , SP, Brazil

Abstract

Nanotechnology is a billion dollar business worldwide because of its huge application potential. The impact on the academic, business and societal sectors is striking and is likely to increase with an ever-increasing flow of investment in the coming years. One of the sectors of nanotechnology with great potential of application are the systems of controlled release of drugs in search of a better therapeutic efficacy. The proposed research project will comprise the study of the synthesis and physical-chemical characterization of polymer nanoparticles for application in controlled release systems using alpha-aryl-N-aryl-Nitrones. The aim will be: morphological evaluation, determination of the incorporation of nitrones in the polymer matrices, stability tests of the activity and cytotoxicity tests of N-aryl-alpha aryl nitrone class molecules incorporated in the polymer matrices, test. Several techniques will be used for physico-chemical characterization (XRD, DSC, TGA, FEG-SE, FTIR and MICRO-RAMAN), in vitro release assays and cytotoxicity tests (cell culture and cell viability) (AU)