Development of Polymeric Carriers for Controlled Release Systems Using alfa-aryl-N-aryl-Nitrones

• Grant number: 17/23405-7
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2018
• End date: December 31, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Márcio Luiz dos Santos
• Grantee: Márcio Luiz dos Santos
• Host Institution: Centro Universitário Anhanguera de São Paulo. São Bernardo do Campo , SP, Brazil
• City of the host institution: São Bernardo do Campo

Abstract

Nanotechnology is a billion dollar business worldwide because of its huge application potential. The impact on the academic, business and societal sectors is striking and is likely to increase with an ever-increasing flow of investment in the coming years. One of the sectors of nanotechnology with great potential of application are the systems of controlled release of drugs in search of a better therapeutic efficacy. The proposed research project will comprise the study of the synthesis and physical-chemical characterization of polymer nanoparticles for application in controlled release systems using alpha-aryl-N-aryl-Nitrones. The aim will be: morphological evaluation, determination of the incorporation of nitrones in the polymer matrices, stability tests of the activity and cytotoxicity tests of N-aryl-alpha aryl nitrone class molecules incorporated in the polymer matrices, test. Several techniques will be used for physico-chemical characterization (XRD, DSC, TGA, FEG-SE, FTIR and MICRO-RAMAN), in vitro release assays and cytotoxicity tests (cell culture and cell viability) (AU)