Scholarship 05/03002-8 - Síntese assimétrica, Síntese orgânica - BV FAPESP
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Synthesis and biological activity of fostriecin analogues

Grant number: 05/03002-8
Support Opportunities:Scholarships in Brazil - Doctorate
Start date until: April 01, 2006
End date until: March 31, 2010
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Ronaldo Aloise Pilli
Grantee:Ilton Barros Daltro de Castro
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The total syntheses of some fostriecin analogues will be carried out based on asymmetric allylation, ring-closing metathesis, aldol reaction and Tishchenko reactions. Both enantiomeric forms of mono- and bisphosphorylated fostriecin analogues will be prepared and their cytotoxic activity against eight human cancer cell lines and inhibition of phosphatases will be evaluated.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CASTRO, Ilton Barros Daltro de. Synthesis and biological activity of fostriecina analogues. 2010. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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