Synthesis and biological activity of fostriecin analogues

• Grant number: 05/03002-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2006
• End date: March 31, 2010
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ronaldo Aloise Pilli
• Grantee: Ilton Barros Daltro de Castro
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The total syntheses of some fostriecin analogues will be carried out based on asymmetric allylation, ring-closing metathesis, aldol reaction and Tishchenko reactions. Both enantiomeric forms of mono- and bisphosphorylated fostriecin analogues will be prepared and their cytotoxic activity against eight human cancer cell lines and inhibition of phosphatases will be evaluated.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CASTRO, Ilton Barros Daltro de. Synthesis and biological activity of fostriecina analogues. 2010. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.