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Enzymatic obtaining of xylitol using Candida guilliermondii xylose reductase as an alternative to fermentative production pathway

Grant number: 05/02840-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2006
Effective date (End): March 31, 2010
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal researcher:Silvio Silvério da Silva
Grantee:Ricardo de Freitas Branco
Home Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil


Xylitol is a sugar-alcohol with important properties for food, odontological and pharmaceutical industries. It is produced, traditionally, by a chemical process which is very expensive. Fermentative process is a cheaper a alternative which has been extensively studied. However, it results in an inevitable lost of substrate fractions, in different metabolic routes, for biomass and subproducts productions. The enzymatic process is an interesting alternative, which could result in a xylose yield closer to the stoicheometric. The enzymatic production of this polyalcohol could result in a substantial productivity increase, since it wouldn't not have mass transfer flow limitations, usual in microbial process. In this context, the present project has as objective to determinate the conditions of the enzymatic process for xilitol production by xilose redutase from Candida guilliermondii FTI 20037. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRANCO, RICARDO DE FREITAS; SILVA, SILVIO S. Contribution of Tris Buffer on Xylitol Enzymatic Production. Applied Biochemistry and Biotechnology, v. 162, n. 6, p. 1558-1563, NOV 2010. Web of Science Citations: 2.
LALUCE, CECILIA; TOGNOLLI, JOAO OLIMPIO; DE OLIVEIRA, KAREN FERNANDA; SOUZA, CRISLA SERRA; MORAIS, MELINE REZENDE. Optimization of temperature, sugar concentration, and inoculum size to maximize ethanol production without significant decrease in yeast cell viability. Applied Microbiology and Biotechnology, v. 83, n. 4, p. 627-637, June 2009. Web of Science Citations: 39.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BRANCO, Ricardo de Freitas. Xylitol enzymatic production using coenzyme regeneration system as an alternative for the chemical and microbial obtainment way. 2010. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Engenharia de Lorena (EEL/ASDI) Lorena.

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