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Evaluation of prohibitin role in developing resistance to chemotherapeutic treatment against melanomas

Grant number: 06/01937-2
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2006
Effective date (End): August 31, 2008
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Roger Chammas
Grantee:Tharcisio Citrangulo Tortelli Junior
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Melanoma incidence is increasing worldwide. Besides its increasing importance in Public Health, melanomas represent a clinical challenge, as their treatment outcome is still poor. Objective responses to chemotherapy is usually lower than 30% in the more advanced cases. The molecular bases for chemoresistance are poorly understood so far. Many authors propose that on knowing the molecular basis for resistance, one could design a more appropriate strategy for treatment. In a previous study involving our group, we had observed an increase in the amounts of prohibitin in melanoma cells which survived cisplatin treatment. Prohibitin is found in several subcellular compartments within the cell. Nuclear prohibitin seems associated with cell death, while mitochondrial prohibitin seems a chaperone to newly synthesized respiratory chain proteins. In this project, our aim is to determine how the compartmentalization of prohibitin associates with response to chemotherapy, the eventual existence of prohibitin isoforms within these distinct cellular compartments and the effects of knocking down prohibitin using siRNA strategy. (AU)

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
JUNIOR, Tharcisio Citrangulo Tortelli. Avaliação do papel de proibitina no desenvolvimento de resistência à cisplatina em linhagens de melanoma humano. 2008. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina São Paulo.

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