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Study of wakefulness and sleep pain threshold using laser-evoked potential

Grant number: 06/03444-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2006
Effective date (End): August 31, 2008
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Sergio Tufik
Grantee:Eduardo Azevedo Pacheco
Home Institution: Departamento de Psicobiologia. Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Nociceptive threshold of humans during wake and sleep will be investigated by means of the laser evoked potential technique. During a polysomnographic examination, twenty healthy adult volunteers will be stimulated on the dorsum of the hand using brief laser pulses, delivered by an automatic device that varies intensity and point of incidence, according to a pre-programmed protocol. Biomedical signal processing techniques will be applied to the off-line recordings in order to calculate the evoked potential and provide an estimation of the nociceptive threshold during sleep stages. Results will help to elucidate the effects of nociceptive stimulation on polysomnographic parameters.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AZEVEDO, EDUARDO; MANZANO, GILBERTO M.; SILVA, ANDRESSA; MARTINS, RAQUEL; ANDERSEN, MONICA L.; TUFIK, SERGIO. The effects of total and REM sleep deprivation on laser-evoked potential threshold and pain perception. Pain, v. 152, n. 9, p. 2052-2058, SEP 2011. Web of Science Citations: 34.

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