Evaluation of hemodynamic response in patients with carotid stenosis under hypercapnia

• Grant number: 06/05706-5
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2007
• End date: September 30, 2008
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Draulio Barros de Araujo
• Grantee: Renata Ferranti Leoni
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Cerebral blood circulation has special characteristics responsible for controlling the relation between functional activity, metabolism and blood flow in the nervous tissue. An important characteristic is the cerebral vasoregulation, responsible for keeping the blood flow constant or for changing it in response to functional necessities. Patients with cerebrovascular diseases, such as carotid stenosis, show a cerebral vasoregulation deficit that can cause cerebral ischemic events. Then, since it has relevance in daily clinical routine, we want to assess the vasoreactivity and the cerebral vascular reserve in patients with severe carotid stenosis or unilateral carotid occlusion, and correlate the changes with collateral patterns, to be evaluated by resonance angiography and transcranial Doppler sonography. To assess the cerebrovascular reserve, we will use fMRI technique and look for specific characteristics of the hemodynamic response function and its changes after vasodilatatory stimuli by inhalation of CO2. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEONI, RENATA F.; PAIVA, FERNANDO F.; KANG, BYEONG-TECK; HENNING, ERICA C.; NASCIMENTO, GEORGE C.; TANNUS, ALBERTO; DE ARAUJO, DRAULIO B.; SILVA, AFONSO C.. Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke. TRANSLATIONAL STROKE RESEARCH, v. 3, n. 1, SI, p. 44-55, MAR 2012. (06/05706-5, 05/56663-1)

LEONI, RENATA F.; PAIVA, FERNANDO F.; HENNING, ERICA C.; NASCIMENTO, GEORGE C.; TANNUS, ALBERTO; DE ARAUJO, DRAULIO B.; SILVA, AFONSO C.. Magnetic resonance imaging quantification of regional cerebral blood flow and cerebrovascular reactivity to carbon dioxide in normotensive and hypertensive rats. NeuroImage, v. 58, n. 1, p. 75-81, SEP 1 2011. (06/05706-5, 05/56663-1)

LEONI, RENATA F.; PAIVA, FERNANDO F.; KANG, BYEONG-TECK; HENNING, ERICA C.; NASCIMENTO, GEORGE C.; TANNUS, ALBERTO; DE ARAUJO, DRAULIO B.; SILVA, AFONSO C.. Arterial Spin Labeling Measurements of Cerebral Perfusion Territories in Experimental Ischemic Stroke. TRANSLATIONAL STROKE RESEARCH, v. 3, n. 1, p. 12-pg., 2012-03-01. (06/05706-5, 05/56663-1)