Enantiomeric determination of pharmaceutical drugs: omeprazole, lansoprazole and pantoprazole in urban wastewater in the city of São Carlos, SP

• Grant number: 06/05126-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2007
• End date: February 28, 2009
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Quezia Bezerra Cass
• Grantee: Kenia Lourenço Vanzolini
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

The proposal of this project consists in the development and validation of analytical method, by liquid chromatography, that allow the determination of the presence of pharmaceutical drugs: omeprazole, lansoprazole and pantoprazole, in the enantiomeric form, in domestic sewage wasted - in nature - at urban area of the municipality of São Carlos–SP. The relevance in the selection of these compounds is associated with the great world wide consume of those substances, as well the local, in the treatment of the acid-related gastrointestinal disorders, such as duodenal, gastric and esophagus ulceration; beyond the use associated with antibiotics, anti-inflammatory, and antidepressives. Besides, once that of the selected compounds: omeprazole, lanzoprazole and pantoprazole are chirals and administered in the racemic form, the behavior of enantiomeric R and S of these compounds will be evaluated considering the developed method, as well the stability and susceptibility to the abiotic and biotic degradation in the environment. The expectative is that the results could be contribute to the knowledge of the environmental occurrence enantiomeric of these pharmaceuticals products for the human consumption. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARREIRO, JULIANA CRISTINA; VANZOLINI, KENIA LOURENCO; MADUREIRA, TANIA VIEIRA; TIRITAN, MARIA ELIZABETH; CASS, QUEZIA BEZERRA. A column-switching method for quantification of the enantiomers of omeprazole in native matrices of waste and estuarine water samples. Talanta, v. 82, n. 1, p. 384-391, JUN 30 2010. (06/05126-9, 08/05778-1)

BARREIRO, JULIANA CRISTINA; VANZOLINI, KENIA LOURENCO; CASS, QUEZIA BEZERRA. Direct injection of native aqueous matrices by achiral-chiral chromatography ion trap mass spectrometry for simultaneous quantification of pantoprazole and lansoprazole enantiomers fractions. Journal of Chromatography A, v. 1218, n. 20, p. 2865-2870, MAY 20 2011. (06/05126-9, 08/05778-1)