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Theoretical and experimental modeling for ACB optimization: a new methodology for quality control in solid dosage forms disintegration

Grant number: 07/02313-5
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2007
Effective date (End): July 31, 2009
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:José Ricardo de Arruda Miranda
Grantee:Paulo Roberto da Fonseca Filho
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Oral drug administration is common in therapeutics and the solid dosage forms are widely used. Drug absorption depends on the disintegration of the solid dosage form and its dissolution in the gastrointestinal fluids. The disintegration process can be influenced by formulation constitution and the parameters related to the human gastrointestinal tract, such as differences in pH, motility patterns and prandial state. However, before performing any application, in vitro studies are needed to ensure the commercialization of a new product. Generally this evaluation goes through a detailed analysis of the disintegration force as a function of time. Hence, several simulation models were proposed.Recently new biomagnetic techniques application was considered on pharmaceutics, including the Alternating Current Biosusceptometry (ACB). The ACB detects magnetic flux variation as a response of a magnetic material when an alternating magnetic field is applied. The main characteristics of this technique are low operation cost, non-invasivity and radiation-free. The ACB was feasible to monitor magnetic solid dosage forms in the human gastrointestinal tract through signals and images as a new method for pharmaceutical research. An effective analysis and correlation between theoretical models and experimental data will be realized to relate the information obtained by this instrumentation to the models used by pharmaceutical technology, aiming a implementation of the ACB method for quality control of solid dosage forms. Moreover, image processing and filtering techniques are needed to enhance, optimize and standardize the magnetic images.Therefore the aim of this study is to apply the multi-sensor ACB to evaluate the in vitro disintegration process of coated magnetic tablets, simulating the influences of different disintegrants and compression forces to model the biomagnetic data and to relate them to the current models used to describe this phenomena.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGO SARTORELO SALEMI VIANA; HELENICE DE OLIVEIRA FLORENTINO; ERNESTO AUGUSTO BUENO DA FONSECA LIMA; PAULO ROBERTO DA FONSECA; THIAGO PEDRO DONADON HOMEM. Heterogeneity correction in the construction of optimized planning in radiotherapy using linear programming. Pesquisa Operacional, v. 31, n. 3, p. -, Dez. 2011.

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