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Effect of concurrent training on gene expression associated with muscle hypertrophy

Grant number: 07/02738-6
Support type:Scholarships in Brazil - Master
Effective date (Start): December 01, 2007
Effective date (End): November 30, 2009
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Carlos Ugrinowitsch
Grantee:Eduardo Oliveira de Souza
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Many athletes perform both strength and endurance training simultaneously. This training routine is called concurrent training (CT). However, this type of training produces an “interference effect” phenomenon, which decreases strength gains. An appealing way to provide explanations for the interference effect during CT would be to analyze different levels of the adaptative process. A possible candidate would be to analyze adaptations at the muscle level. Muscle components (e.g sarcoplasmic reticulum, mitochondria, and mypfibrils) seem to compete for space within the muscle fiber. In addition, pathways activation seems to respond differently to strength training (ST) and to endurance training (END). Animal studies have provided evidence that ST and END result in a selective activation of molecular pathways. Phosphorylated protein kinases (AMPK) during END leads to the inactivation of another kinase (AKT), which may decrease protein synthesis and strength adaptations.Thus, the purpose of this study will be to investigat the morphologic adaptations in the myofibrils, sarcoplasmatic reticulum and mitochondria and with the expression of kinases that regulate CT adaptations. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, E. O.; TRICOLI, V.; ROSCHEL, H.; BRUM, P. C.; BACURAU, A. V. N.; FERREIRA, J. C. B.; AOKI, M. S.; NEVES-, JR., M.; AIHARA, A. Y.; CORREA FERNANDES, A. DA ROCHA; UGRINOWITSCH, C. Molecular Adaptations to Concurrent Training. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 34, n. 3, p. 207-213, MAR 2013. Web of Science Citations: 22.
E.O.DE SOUZA; V. TRICOLI; C. BUENO JUNIOR; M.G. PEREIRA; P.C. BRUM; E.M. OLIVEIRA; H. ROSCHEL; M.S. AOKI; C. URGINOWITSCH. The acute effects of strength, endurance and concurrent exercises on the Akt/mTOR/p70S6K1 and AMPK signaling pathway responses in rat skeletal muscle. Brazilian Journal of Medical and Biological Research, v. 46, n. 4, p. -, Abr. 2013.
DE SOUZA, E. O.; TRICOLI, V.; BUENO JUNIOR, C.; PEREIRA, M. G.; BRUM, P. C.; OLIVEIRA, E. M.; ROSCHEL, H.; AOKI, M. S.; URGINOWITSCH, C. The acute effects of strength, endurance and concurrent exercises on the Akt/mTOR/p70(S6K1) and AMPK signaling pathway responses in rat skeletal muscle. Brazilian Journal of Medical and Biological Research, v. 46, n. 4, p. 343-347, Abr. 2013. Web of Science Citations: 3.
DE SOUZA, E. O.; TRICOLI, V.; PAULO, A. C.; SILVA-BATISTA, C.; CARDOSO, R. K.; BRUM, P. C.; BACURAU, A. V. N.; LAURENTINO, G.; NEVES-, JR., M.; AIHARA, A. Y.; UGRINOWITSCH, C. Multivariate Analysis in the Maximum Strength Performance. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 33, n. 12, p. 970-974, DEC 2012. Web of Science Citations: 3.
DE SOUZA, EDUARDO OLIVEIRA; CAINELI ROSA, LUIS FERNANDO; PIRES, FLAVIO DE OLIVEIRA; WILSON, JACOB; FRANCHINI, EMERSON; TRICOLI, VALMOR; UGRINOWITSCH, CARLOS. The acute effects of varying strength exercises bouts on 5km running. JOURNAL OF SPORTS SCIENCE AND MEDICINE, v. 10, n. 3, p. 565-570, SEP 2011. Web of Science Citations: 5.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Eduardo Oliveira de. Effect of concurrent training on gene and protein expression associated with skeletal muscle hypertrophy. 2010. Master's Dissertation - Universidade de São Paulo (USP). Escola de Educação Física e Esportes (EEFE/BT) São Paulo.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.