Studies on the biotransformation of two fungal diterpene class of pimaranos by Aspergillus ochraceus and biological evaluation of the metabolites obtained.

• Grant number: 08/07696-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2009
• End date: February 28, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Sergio Ricardo Ambrosio
• Grantee: Thiago Sousa Porto
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated research grant: 07/54762-8 - Obtaining structural analogues of pimaradienoic acid through the process of fungal biotransformation and study of the effect of these metabolites on the activity of the TcDHODH enzyme and on the contraction of the vascular smooth muscle of the aorta artery of mice, AP.BTA.JP

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PORTO, THIAGO S.; SIMAO, MARILIA R.; CARLOS, LUCAS Z.; MARTINS, CARLOS H. G.; FURTADO, NIEGE A. J. C.; SAID, SURAIA; ARAKAWA, NILTON S.; DOS SANTOS, RAQUEL A.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R.. Pimarane-type Diterpenes Obtained by Biotransformation: Antimicrobial Properties Against Clinically Isolated Gram-positive Multidrug-resistant Bacteria. Phytotherapy Research, v. 27, n. 10, p. 1502-1507, OCT 2013. (07/54762-8, 08/07696-2)

PORTO, THIAGO S.; DA SILVA FILHO, ADEMAR A.; MAGALHAES, LIZANDRA G.; DOS SANTOS, RAQUEL A.; FURTADO, NIEGE A. J. C.; ARAKAWA, NILTON S.; SAID, SURAIA; DE OLIVEIRA, DIONEIA C. R.; GREGORIO, LUIZ E.; RODRIGUES, VANDERLEI; et al. Fungal Transformation and Schistosomicidal Effects of Pimaradienoic Acid. CHEMISTRY & BIODIVERSITY, v. 9, n. 8, p. 1465-1474, AUG 2012. (07/54762-8, 08/07696-2)