Functional activity of milk phagocytes in mothers with mild hyperglycemia and diabetes and their neuroimmunendocrinology regulation

• Grant number: 09/01188-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2009
• End date: October 31, 2012
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Iracema de Mattos Paranhos Calderon
• Grantee: Glilciane Morceli
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Diabetic women have been encouraged to breastfeed for reasons that include a possible reduction in the risk of diabetes in their children. Evidence experimental and epidemiological suggest that diet may be important in the pathogenesis of diabetes. In the literature suggest that breast milk may be a factor for the protection of diabetes, and this effect is due to the anti-infective factors, or the fact that breastfeeding to prevent that children are exposed early to other etiologic agents contained in milk substitutes. Thus, the aim of this study is to evaluate the interactions between soluble factors (antibodies and hormone) and cell present in the colostrum of mild hyperglycemic and diabetic mothers. It is expected to develop this project to better understand the interactions between the soluble and cellular elements present in colostrum and breast milk of diabetic mothers, and improve maternal and child health, as in Brazil and developing countries maternal morbidity and mortality and children are still regarded as a public health problem. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CALDERON, I.; MORCELI, G.; HARA, C.; VOLPATO, R.; RUDGE, M.; HONORIO-FRANCA, A.; FRANCA, E.; BENRAFAEL, Z; FAUSER, BCJM; FRYDMAN, R. Effect of melatonin on the oxidative metabolism of colostrum phagocytes of diabetic women. 14TH WORLD CONGRESS ON CONTROVERSIES IN OBSTETRICS, GYNECOLOGY & INFERTILITY (COGI), v. N/A, p. 4-pg., 2011-01-01. (09/01188-8, 08/09187-8)

FRANCA, EDUARDO LUZIA; PARANHOS CALDERON, IRACEMA DE MATTOS; VIEIRA, ELISA LIMA; MORCELI, GLILCIANE; HONORIO-FRANCA, ADENILDA CRISTINA. Transfer of Maternal Immunity to Newborns of Diabetic Mothers. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2012. (09/01188-8, 11/18045-5)

MORCELI, GLICIANE; HONORIO-FRANCA, ADENILDA C.; FAGUNDES, DANNY L. G.; CALDERON, IRACEMA M. P.; FRANCA, EDUARDO L.. Antioxidant Effect of Melatonin on the Functional Activity of Colostral Phagocytes in Diabetic Women. PLoS One, v. 8, n. 2, FEB 20 2013. (09/01188-8, 11/18045-5, 08/09187-8)

FRANCA, EDUARDO LUZIA; MORCELI, GLILCIANE; GOMES FAGUNDES, DANNY LAURA; CUNHA RUDGE, MARILZA VIEIRA; PARANHOS CALDERON, IRACEMA DE MATTOS; HONORIO-FRANCA, ADENILDA CRISTINA. Secretory IgA-Fc alpha receptor interaction modulating phagocytosis and microbicidal activity by phagocytes in human colostrum of diabetics. APMIS, v. 119, n. 10, p. 710-719, OCT 2011. (09/01188-8)

MORCELI, G.; FRANCA, E. L.; MAGALHAES, V. B.; DAMASCENO, D. C.; CALDERON, I. M. P.; HONORIO-FRANCA, A. C.. Diabetes induced immunological and biochemical changes in human colostrum. ACTA PAEDIATRICA, v. 100, n. 4, p. 550-556, APR 2011. (09/01188-8)

FRANCA, EDUARDO LUZIA; PARANHOS CALDERON, IRACEMA DE MATTOS; VIEIRA, ELISA LIMA; MORCELI, GLILCIANE; HONORIO-FRANCA, ADENILDA CRISTINA. Transfer of Maternal Immunity to Newborns of Diabetic Mothers. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, v. N/A, p. 7-pg., 2012-01-01. (09/01188-8, 11/18045-5, 08/09187-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MORCELI, Glilciane. Atividade funcional de fagócitos do leite de mães hiperglicêmicas leve e diabéticas e sua regulação neuroimunoendocrinológica: interações com lgA e melatonina. 2012. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.