Studies on the synthesis of a polar fragment exhibit by antiepileptics ceramides isolated from marine source, using a Morita-Baylis-Hillman

• Grant number: 09/03718-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2009
• End date: July 31, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Fernando Antonio Santos Coelho
• Grantee: Nathalia Christina Gonçalves Yamakawa
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This Master research project is focused on the establishment of a synthetic sequence for the preparation of a polar fragment which occurs in sphingosides and ceramides isolated from natural source. Some of these natural compounds exhibit a potent antiepileptic activity. The strategy is based on a Morita-Baylis-Hillman reaction between a chiral aldehyde, easily prepared from a natural aminoacid, and methyl acrylate. This adduct will be used as substrate for the preparation of the desired fragment through a direct synthetic sequence. The success of this research proposal will allow us synthesize several biologically active natural sphingoside and ceramides. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

YAMAKAWA, Nathalia Christina Gonçalves. Epilepsy and Morita-Baylis-Hillman: a synthetic approach to antiepileptic. 2011. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.