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Peptides of various types of collagen and its role antihypertensives

Grant number: 09/12177-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2010
Effective date (End): August 31, 2011
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Jocelem Mastrodi Salgado
Grantee:Zilmar Meireles Pimenta Barros
Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil


Hypertension is characterized by increased blood pressure and represents a risk factor for cardiovascular disease, with medical costs and socioeconomic levels, stemming from its complications. The prevalence of hypertension is influenced by a number of factors such as age, sex, ethnicity, socioeconomic status and diet. Control mechanisms of hypertension are varied, however, the Renin-Angiotensin System stands out because it involves the mechanism of action of angiotensin-converting enzyme (ACE), involved in the control of hypertension through vasoconstriction. Protein foods have attracted the interest of researchers, due to a series of evidence to show they have bioactive compounds with anti-hypertensive. Collagen, a protein of importance in several metabolic processes of the body, when hydrolyzed, can display anti-hypertensive property. Collagens from different sources are studied and related to the inhibitory activity of ACE, with antihypertensive effects. This project has as objective to evaluate the antihypertensive activity of peptides derived from hydrolysates of different types of collagen in vitro and also the activity of gastrointestinal enzymes on these bioactive peptides. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BARROS, Zilmar Meireles Pimenta. Tropical fruit peels as a source of antioxidant for ready juice enrichment. 2011. Master's Dissertation - Universidade de São Paulo (USP). Escola Superior de Agricultura Luiz de Queiroz (ESALA/BC) Piracicaba.

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