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Fungal biotransformation of the pimaradienoic acid by Aspergillus niger and evaluation of the inhibitory effect on rat aorta contraction of the obtained derivatives

Grant number: 09/12458-6
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2010
Effective date (End): February 29, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Sergio Ricardo Ambrosio
Grantee:Marcela Etchebehere Severiano
Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
Associated research grant:07/54762-8 - Obtaining structural analogues of pimaradienoic acid through the process of fungal biotransformation and study of the effect of these metabolites on the activity of the TcDHODH enzyme and on the contraction of the vascular smooth muscle of the aorta artery of mice, AP.BTA.JP
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SEVERIANO, MARCELA E.; SIMAO, MARILIA R.; RAMOS, HENRIQUE P.; PARREIRA, RENATO L. T.; ARAKAWA, NILTON S.; SAID, SURAIA; FURTADO, NIEGE A. J. C.; DE OLIVEIRA, DIONEIA C. R.; GREGORIO, LUIS E.; TIRAPELLI, CARLOS R.; et al. Biotransformation of ent-pimaradienoic acid by cell cultures of Aspergillus niger. Bioorganic & Medicinal Chemistry, v. 21, n. 18, p. 5870-5875, . (09/12458-6, 07/54762-8)

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