Advanced search
Start date
Betweenand

Assessment of enantiomeric antimalarial drugs using capillary electrophoresis

Grant number: 09/13072-4
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2010
Effective date (End): February 29, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Marina Franco Maggi Tavares
Grantee:Karina Trevisan Rodrigues
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

This project aims at developing a method for chiral separation of 8 antimalarial drugs (chloroquine, hydroxychloroquine, primaquine, mefloquine, halofantina, quinacrine, quinine and quinidine) by capillary electrophoresis. Separations will be studied in micellar media containing chiral selectors (cyclodextrins and chemically modified cyclodextrins). Therefore, the interaction constant of solute-micelle and solute-cyclodextrin will be determined experimentally and effective mobility curves as a function of concentration of the chiral selector will be built. The type and concentration of chiral selector is then selected for the 8 drugs under study and will compose the optomized electrolyte system. The proposed method is validated according to pharmacopeic protocols and applied to the quality control of commercially available pharmaceutical formulations and eventually it will be tested in the establishment of conditions for inspection of such drugs in biological matrices(lyophilized human serum).