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Morfoquantitave evaluation of the expressions of IGF-I, insulin and their receptors on dental pulp and junctional epithelium of the pubescent wistar rats after pre and postnatal protein undernutrition and postnatal refeeding

Grant number: 10/04845-7
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2010
Effective date (End): January 31, 2012
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Edson Aparecido Liberti
Grantee:Aline Gonçalves
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Nutritional and metabolic factors are able to undertake the full development of dental tissues, especially when they impinge on critical periods. Studies show that issues arising from malnutrition and too late, and the activity of insulin and IGF-1, are related to some diseases and point, mostly permanent basis in high level, if not immediate, prospective, compromising performance morphological and functional tissue. Thus, this study aims to recognize the effects of protein pre-and post-natal and postnatal renutrição on the growth of the dental pulp and of the junctional epithelium of periodontal tissue and its relation to the activity of insulin and IGF1, seeking a possible correlation between the metabolic and morphological changes found in a previous study with the activity of these important hormones on these tissues, in pubertal and adult stages. Therefore, the experimental groups will be formed by heterogenic animals (n = 5) according to the ration offered, protein or low protein, and their ages, the groups N, D (nourished and malnourished after 60 days of life on stage which the pubertal period is finite), R (renutridos from 21 until they reach 60 days of life), NN (fed up to 100 days of life) and RR (renutridos from weaning until they reached 100 days of life). After euthanasia, specimens obtained will be processed for light microscopy, and sectioned frontally obtained shall be submitted to immunohistochemistry for the identification of IGF1, insulin and their receptors. Immunoreactive cells will be quantified and the results will be analyzed statistically.

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