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Effect of supplementation of Vitamins C and e on oxidative stress associated with iron in hemodialysis patients

Grant number: 10/07157-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2010
Effective date (End): October 31, 2013
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Paula Garcia Chiarello
Grantee:Letícia Bertoldi Sanches
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Anemia in dialysis patients is common and includes deficiency of erythropoietin (Epo), treated by hormone replacement therapy and oral and intravenous iron that, in its free form, mainly contributes to the increased production of radical species and to the chronic oxidative stress observed in these patients. In an attempt to reduce this pro-oxidative environment caused by treatments (dialysis and anemia) and renal failure, vitamins C and E might be effective. Therefore, the aim of this study is to evaluate and compare oxidative stress (protein and lipid) in iron therapies, and evaluate supplementations of vitamins C and E hemodialysis patients, with intravenous and oral supplementation of iron, which will receive oral doses of vitamins C and E, singly and jointly, for periods of three months. At baseline and at the end of vitamins supplementations periods analysis will be taken: routine biochemical parameters in dialysis, quantification of lipid and protein oxidative stress, inflammatory markers and antioxidant vitamins. Nutritional status will be evaluated by means of dietary, biochemical and anthropometric data. The associations among variables will be evaluated by correlation tests, the differences between groups will be made by comparing means and will be conducted multivariate regression analysis.