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Cytotoxic and genotoxic effects of nanoparticles in cell lines in vitro.

Grant number: 10/10863-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2010
Effective date (End): July 31, 2014
Field of knowledge:Biological Sciences - Genetics - Mutagenesis
Principal researcher:Catarina Satie Takahashi
Grantee:Leonardo Pereira Franchi
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Nanotechnology promises to exceed the impact of the Industrial Revolution and it is projected to become a market of one trillion dollars in 2015. Nanomaterials (NM) are already being used in sports equipment, tires, stain-resistant clothing, sunscreens, cosmetics and electronics. The rapid development in nanotechnology has led, as well as other technological advances, the prediction of major benefits and also great dangers to humanity and the ecosystem. Therefore, the aim of this study is to establish the responses of three human cell lines regarding cell viability (XTT) and clonogenic survival, cell death, and genotoxicity (Comet Assay and micronucleus test) when treated with titanium dioxide and cerium dioxide nanoparticles and carbon nanotubes. So, given the considerable uncertainty about the safety of using NM, it is important to understand and subsequently minimize any potential toxicity associated with them, not only to protect human health and the ecosystem, but also to provide the safe growth of nanotechnology.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FRANCHI, L. P.; DE SOUZA, T. A. J.; ANDRIOLI, W. J.; LIMA, I. M. S.; BASTOS, J. K.; TAKAHASHI, C. S. The effects of the mycotoxin austdiol on cell cycle progression, cytotoxicity and genotoxicity in Chinese hamster ovary (CHO-K1) cells. WORLD MYCOTOXIN JOURNAL, v. 9, n. 2, p. 237-246, 2016. Web of Science Citations: 1.
FRANCHI, LEONARDO P.; MANSHIAN, BELLA B.; DE SOUZA, TIAGO A. J.; SOENEN, STEFAAN J.; MATSUBARA, ELAINE Y.; ROSOLEN, J. MAURICIO; TAKAHASHI, CATARINA S. Cyto- and genotoxic effects of metallic nanoparticles in untransformed human fibroblast. TOXICOLOGY IN VITRO, v. 29, n. 7, p. 1319-1331, OCT 2015. Web of Science Citations: 26.
DE SOUZA FILHO, JOSE; MATSUBARA, ELAINE Y.; FRANCHI, LEONARDO PEREIRA; MARTINS, IGOR PINHEIRO; RAMIRES RIVERA, LUIS MIGUEL; ROSOLEN, JOSE MAURICIO; GRISOLIA, CESAR KOPPE. Evaluation of carbon nanotubes network toxicity in zebrafish (danio rerio) model. Environmental Research, v. 134, n. SI, p. 9-16, OCT 2014. Web of Science Citations: 16.
LEONARDO P. FRANCHI; RAQUEL A. SANTOS; ELAINE Y. MATSUBARA; JULIANA C. DE LIMA; J. MAURÍCIO ROSOLEN; CATARINA S. TAKAHASHI. Citotoxicidade e genotoxicidade de nanotubos de carbono. Química Nova, v. 35, n. 3, p. 571-580, 2012.

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