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BIODEGRADABLE POLYMERS CONTAINING PROANTOCIANIDINES TO ACCELERATE HEALING OF DIABETIC CHRONIC WOUNDS

Grant number: 10/14273-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2011
Effective date (End): February 28, 2013
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Marinilce Fagundes dos Santos
Grantee:Juliana da Costa Florim
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Diabetes Mellitus (DM) is a chronic disease that affects more than 150 million people worldwide. Brazil is among the top 10 countries with the highest incidence of DM. Independently of its etiology, DM is defined by the World Health Organization as a group of metabolic disorders characterized by chronic hyperglycemia. Hyperglycemia causes several complications, including impaired wound healing, which leads to chronic wounds. These represent a heavy financial burden for the public health system. We have recently demonstrated that high glucose concentrations suppress fibroblasts migration, which might contribute to the delayed wound healing (Lamers et al., under review). This effect of glucose is mostly dependent on reactive oxygen species generated by altered metabolic pathways under hyperglycemia. In the present study we intend to evaluate the efficacy of the treatment of mice diabetic wounds using proantocianidines, potent antioxidants extracted from the grape seeds. As vehicles for this treatment we will use biodegradable polymers (nanofibers and microspheres), nanotechnology tools that allow better dermis penetration and sustained delivery. Wound healing dynamics, the presence of myofibroblasts, angiogenesis, extracellular matrix alterations and the expression of several metalloproteinases will be studied. According to the results, with expect to be able to test this treatment in human chronic wounds, implementing a new, effective and not expensive therapy.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCAL PESSOA, ANA FLAVIA; FLORIM, JULIANA COSTA; RODRIGUES, HOSANA GOMES; ANDRADE-OLIVEIRA, VINICIUS; TEIXEIRA, SIMONE A.; VITZEL, KAIO FERNANDO; CURI, RUI; SARAIVA CAMARA, NIELS OLSEN; MUSCARA, MARCELO N.; LAMERS, MARCELO LAZZARON; et al. Oral administration of antioxidants improves skin wound healing in diabetic mice. WOUND REPAIR AND REGENERATION, v. 24, n. 6, p. 981-993, . (10/14273-0, 12/03990-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FLORIM, Juliana da Costa. Effects of solid lipid nanoparticles containing grape seed extract in diabetic mice cutaneous wound healing.. 2013. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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