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White matter integrity of the corpus callosum and neuropsychological performance in maltreated children and adolescents: a brain morphometric and diffusion tensor imaging study

Grant number: 10/15604-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2010
Effective date (End): November 30, 2013
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Geraldo Busatto Filho
Grantee:Paulo Jannuzzi Cunha
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Despite the high prevalence of children and adolescent maltreatment (CAM), research studies evaluating the effects of maltreatment on brain anatomy and neuropsychological functioning in this population are still limited. There is evidence of reduced volume of the corpus callosum (CC) in association with CAM, but no study to date has evaluated the association between abnormalities of white matter (WM) tracts in the CC, interhemispheric transfer of information, and decision making, taking into account the period when the maltreatment has began. The aim of this study is to investigate the relationship between integrity, size and deformity of the CC, interhemispheric transfer of somatosensory information, and decision making in maltreated children and adolescents. The sample consists of 100 children and adolescents, between 8-17 years old, divided in 60 maltreated and 40 control individuals. They will undergo brain magnetic resonance imaging (MRI) scanning; white matter integrity, regional volumes, and surface patterns of the CC will be determined by methods combining Diffusion Tensor Imaging (DTI), Voxel-Based Morphometry (VBM), and Surface-Based Modeling (SBM), respectively. Neuropsychological assessment will consist of the Crossed Finger Localization Test (CFLT), Wechsler Intelligence Scale for Children - Third Edition (WISC-III), and the Iowa Gambling Task (IGT). We aim to detect early abnormalities that may predispose individuals who suffered CAM to later psychopathological and cognitive impairments, in the hope that such data may reinforce the need to generate future preventive and rehabilitation interventions in Public Health. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre a bolsa:
Cocaine use during adolescence is even more harmful than during adulthood 
Cognitive rehabilitation helps to treat chemical dependents  
Articles published in other midia outlets: (29 total)
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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIM, DANIELLE RUIZ; GONCALVES, PRISCILA DIB; OMETTO, MARIELLA; MALBERGIER, ANDRE; AMARAL, RICARDO ABRANTES; DOS SANTOS, BERNARDO; CAVALLET, MIKAEL; CHAIM-AVANCINI, TIFFANY; SERPA, MAURICIO HENRIQUES; KOBUTI FERREIRA, LUIZ ROBERTO; DE SOUZA DURAN, FABIO LUIS; ZANETTI, MARCUS VINICIUS; NICASTR, SERGIO; BUSATTO, GERALDO FILHO; ANDRAD, ARTHUR GUERRA; CUNH, PAULO JANNUZZI. The role of neurocognitive functioning, substance use variables and the DSM-5 severity scale in cocaine relapse: A prospective study. DRUG AND ALCOHOL DEPENDENCE, v. 197, p. 255-261, APR 1 2019. Web of Science Citations: 0.
OLIVEIRA, HERCILIO P.; GONCALVES, PRISCILA D.; OMETTO, MARIELLA; SANTOS, BERNARDO; MALBERGIER, ANDRE; AMARAL, RICARDO; NICASTRI, SERGIO; ANDRADE, ARTHUR G.; CUNHA, PAULO J. The Route of Administration Exacerbates Prefrontal Functional Impairments in Crack Cocaine Users. PSYCHOLOGY OF ADDICTIVE BEHAVIORS, v. 32, n. 7, p. 812-820, NOV 2018. Web of Science Citations: 0.
LOPES, BRUNA MAYARA; GONCALVES, PRISCILA DIB; OMETTO, MARIELLA; DOS SANTOS, BERNARDO; CAVALLET, MIKAEL; CHAIM-AVANCINI, TIFFANY MOUKBEL; SERPA, MAURICIO HENRIQUES; NICASTRI, SERGIO; MALBERGIER, ANDRE; BUSATTO, GERALDO F.; DE ANDRADE, ARTHUR GUERRA; CUNHA, PAULO JANNUZZI. Distinct cognitive performance and patterns of drug use among early and late onset cocaine users. ADDICTIVE BEHAVIORS, v. 73, p. 41-47, OCT 2017. Web of Science Citations: 5.
VIDAL MILIONI, ANA LUIZA; CHAIM, TIFFANY MOUKBEL; CAVALLET, MIKAEL; DE OLIVEIRA, NATHALYA MOLEDA; ANNES, MARCO; DOS SANTOS, BERNARDO; LOUZA, MARIO; DA SILVA, MARIA APARECIDA; MIGUEL, CARMEN SILVIA; SERPA, MAURICIO HENRIQUES; ZANETTI, MARCUS V.; BUSATTO, GERALDO; CUNHA, PAULO JANNUZZI. High IQ May ``Mask{''} the Diagnosis of ADHD by Compensating for Deficits in Executive Functions in Treatment-Naive Adults With ADHD. JOURNAL OF ATTENTION DISORDERS, v. 21, n. 6, p. 455-464, APR 2017. Web of Science Citations: 10.
OMETTO, MARIELLA; DE OLIVEIRA, PAULA APPROBATO; MILIONI, ANA LUIZA; DOS SANTOS, BERNARDO; SCIVOLETTO, SANDRA; BUSATTO, GERALDO F.; NUNES, PAULA V.; CUNHA, PAULO JANNUZZI. Social skills and psychopathic traits in maltreated adolescents. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 25, n. 4, p. 397-405, APR 2016. Web of Science Citations: 6.
PAULO JANNUZZI CUNHA; PAULA APPROBATO DE OLIVEIRA; MARIANA CORTEZZI; GERALDO F. BUSATTO; SANDRA SCIVOLETTO. Executive dysfunction and low academic attainment in adolescent substance abusers with a history of maltreatment. MedicalExpress (São Paulo, online), v. 2, n. 6, p. -, Dez. 2015.
SCIVOLETTO, SANDRA; SILVA, THIAGO F.; CUNHA, PAULO JANNUZZI; ROSENHECK, ROBERT A. The impact of psychiatric diagnosis on treatment adherence and duration among victimized children and adolescents in Sao Paulo, Brazil. Clinics, v. 67, n. 1, p. 3-9, 2012. Web of Science Citations: 6.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.