DETERMINATION OF CARDIAC MARKERS IN MAINE COON CATS GENETICALLY TESTED FOR HYPERTROPHIC CARDIOMYOPATHY MUTATION

• Grant number: 10/02317-3
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): March 01, 2011
• Effective date (End): June 30, 2012
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Maria Helena Matiko Akao Larsson
• Grantee: Paula Hiromi Itikawa
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Hypertrophic cardiomyopathy (HCM) is the most common feline heart disease and is responsible for high morbidity and mortality rates. Sarcomere disorganization in the affected myocardium of cats with HCM is related to the myosin binding protein C (MYBPC3) gene mutation. In the diagnosis of human heart disease have increased the use of biomarkers such as natriuretic peptides ANP (atrial natriuretic peptide) and BNP (brain natriretic peptide) released by stress myocardial atria (ANP) and ventricular (BNP); cardiac troponin I (cTnI), sensitive and specific to diagnosis of myocardial infarction; and endothelin, a potent vasoconstrictor peptide whose plasma concentration increases in patients with heart failure (HF). HCM is diagnosed by conventional echocardiography (CE) through segmental or diffuse myocardial hypertrophy. Cardiac markers (ANP, BNP, cTnI and endothelin) will be determined after ECG, CE, digital thoracic radiography, measurement of blood pressure. Current research in veterinary medicine demonstrated significant differences in the measurement of ANP, BNP and endothelin compared to healthy animals, asymptomatic and symptomatic heart disease, and marked increase in the concentration of plasma cTnI in cats with HCM compared with healthy cats. The study will evaluate Maine Coon cats tested for genetically MYBPC3 mutation to demonstrate how changes in cardiac markers may help in early diagnosis of HCM which assists in medical treatment for the prevention of HF.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ITIKAWA, PAULA HIROMI; GOLDFEDER, GUILHERME TEIXEIRA; COSTA DE OLIVEIRA, VALERIA MARINHO; MATIKO AKAO LARSSON, MARIA HELENA. Serum endothelin-1 measurement in healthy Maine Coon cats. SEMINA-CIENCIAS AGRARIAS, v. 34, n. 6, 2, p. 3831-3839, 2013. (09/54251-9, 10/02317-3)

ITIKAWA, PAULA HIROMI; GOLDFEDER, GUILHERME TEIXEIRA; COSTA DE OLIVEIRA, VALERIA MARINHO; MATIKO AKAO LARSSON, MARIA HELENA. Serum endothelin-1 measurement in healthy Maine Coon cats. SEMINA-CIENCIAS AGRARIAS, v. 34, n. 6, p. 9-pg., 2013-01-01. (09/54251-9, 10/02317-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ITIKAWA, Paula Hiromi. Cardiac biomarkers in Maine Coon cats genetically tested for hypertrophic cardiomyopathy. 2012. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.