Chemical and pharmacological study of Machaerium hirtum (Fabaceae)

• Grant number: 11/02527-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2011
• End date: July 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Miriam Sannomiya
• Grantee: Nelly Cristina Venite de Souza Maria
• Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The main of this project is contribute to the knowledge of the potentiality of the some Machaerium species from the Brazilian Cerrado by a chemical-pharmacological study, in other words, isolation and identification of the compounds presented in the vegetable extracts together with pharmacological assays to the antiulcer, anti-inflamatory/analgesic, anti-mutagenic and mutagenic activities. According to the literature, some Machaerium species (Fabaceae) are ethnopharmacologic used like as Machaerium hirtum (vell.) Stellfedl., it is a plant which barks are employed popularly against diarrhoea, cough and cancer. It is popularly known as "adolfo and bico-de andorinha". Despite of it, no data until now can be observed approaching the chemistry or pharmacological studies with this species.