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Synthesis of biologically active phenols and derivatives

Grant number: 11/00432-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2011
Effective date (End): December 31, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:José Agustín Pablo Quincoces Suárez
Grantee:José Matheus Freitas Costa
Home Institution: Coordenadoria de Pesquisa. Universidade Bandeirantes (UNIBAN). São Paulo , SP, Brazil

Abstract

We planed the synthesis of 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB1 and derivatives. The analgesic properties of this molecule will be determined (analgesic assay in rats). Therefore, we planed the use of this molecule as pH indicator.The synthesis of push-pull butadienes starting from hydroxyacetophenones shall be realized under Vilsmeier-Haack and Knoevenagel reaction conditions. All the compounds will be purified and their structure shall be characterized by spectroscopic methods and organic elemental quantitative analysis.