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In vitro cardiac function of the African catfish Clarias gariepinus

Grant number: 11/07645-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2011
Effective date (End): December 31, 2011
Field of knowledge:Biological Sciences - Physiology - Compared Physiology
Principal Investigator:Francisco Tadeu Rantin
Grantee:Nathalia Usun Jejcic
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


Due to a probable difference between the heart of ectothermic and endothermic species in relation to the influx of calcium in excitation-contraction coupling, studies on cardiac contractility in fish, especially tropical and accessory air breathing, as the African catfish, Clarias gariepinus, become very important. In these animals the mechanisms of calcium control and functionality of the sarcoplasmic reticulum in cardiac contractility are still poorly known. This study aims to analyze the cardiac performance of African catfish, Clarias gariepinus, which, besides being a tropical species, also presents accessory air breathing. To analyze the cardiac contractility of these animals, records of isometric force in ventricular strips, at 25 °C, will be performed to assess the effect of time, the functionality of the sarcoplasmic reticulum, the role of Na+/ Ca2+, the ability of cardiac tissue in the excitation-contraction coupling when stimulation frequencies and adrenaline are changed. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONTEIRO, DIANA AMARAL; LOPES, ANDRE GUELLI; JEJCIC, NATHALIA USUN; DA SILVA VASCONCELOS, ELITON; KALININ, ANA LUCIA; RANTIN, FRANCISCO TADEU. Cardiac contractility of the African sharptooth catfish, Clarias gariepinus: role of extracellular Ca2+, sarcoplasmic reticulum, and beta-adrenergic stimulation. FISH PHYSIOLOGY AND BIOCHEMISTRY, v. 47, n. 6, . (08/57712-4, 11/07645-1)

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