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Investigation of the role of TCTP (translationally Controlled Tumour Protein) in plants using differential expression and production of plants expressing untranslatable transcripts

Grant number: 11/10309-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2011
Effective date (End): September 30, 2012
Field of knowledge:Biological Sciences - Genetics - Plant Genetics
Principal researcher:Ivan de Godoy Maia
Grantee:Márcio de Carvalho
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


The gene encoding TCTP (translationally Controlled Tumour Protein) is present in all eukaryotes and its product is involved in various cellular processes. Although well characterized in mammals, there are few jobs available in the literature related to the analysis of TCTP in plants. Experimental data indicate that protein TCTP can bind to other proteins and regulate the activity of the same, as well as participating in regulatory factor signaling pathways, especially TOR, and some GTPases. In mammals, their mRNA also has the ability to bind to some proteins and regulate them, suggesting that the transcripts of TCTP may participate in regulation of other signaling pathways. This project aims at first, perform an analysis of differential gene into tobacco plants capable of expressing TCTP super tomato compared to wild tobacco plants. It is intended, in parallel to analyze the expression of candidate genes involved in the TOR signaling pathway in these transgenic plants subjected to biotic and abiotic stresses. In addition, transgenic tobacco plants expressing an untranslatable version of TCTP are generated in order to investigate the possible role of the corresponding transcript.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CARVALHO, MARCIO; ACENCIO, MARCIO LUIS; NUNES LAITZ, ALESSANDRA VASCONCELLOS; DE ARAUJO, LAURA MIGLIORINI; CAMPOS ARCURI, MARIANA DE LARA; DO NASCIMENTO, LEANDRO COSTA; MAIA, IVAN G. Impacts of the overexpression of a tomato translationally controlled tumor protein (TCTP) in tobacco revealed by phenotypic and transcriptomic analysis. Plant Cell Reports, v. 36, n. 6, p. 887-900, JUN 2017. Web of Science Citations: 2.

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