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Studies towards the potential application of Streptomyces in biocatalysis reactions

Grant number: 11/14910-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2011
Effective date (End): March 31, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Carlos Henrique Inacio Ramos
Grantee:Lucas Henrique Colombo
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Microorganisms, plants and animals produce a wide range of compounds that cold act as drugs, pigments, fragrances, flavorings and cosmetics. The biosynthesis of such metabolites is mediated by multienzymes complexes acting since the cabonic chain extension to the post-modifying steps. The versatility of such enzymes could be applicable to bioconversions of xenobiotics in order to obtain chiral blocks. We intend to study in this project the capacity of strptomyces strains to promote biotransformations mediated by monooxigenases, oxido-reductases and hydrolysis using whole cell systems.

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