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Effect of ovariectomy in tooth replantation: immunohistochemical analysis in female rats

Grant number: 11/16239-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2011
Effective date (End): September 30, 2012
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal researcher:Sonia Regina Panzarini
Grantee:Vanessa Ferreira da Silva
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Osteoporosis is a disease that dentists normally face in the dental clinic which is caused by an imbalance between the processes of bone formation / resorption.Considering the shortage of publications about dentoalveolar trauma in osteoporotic patients, the study aims to analyze the healing process of immediately tooth replantation in osteoporosis rats by means of immunohistochemical analysis. Rats estrous cycle was studied for 10 days, subsequently, 40 animals with regular cycle were selected for the study. Surgical exposure of the ovaries was performed; group I - sham and group II - ovariectomy (OVX). Tooth extraction and immediately tooth replantation was performed two months after sham or OVX surgery. The animals were euthanized 7 and 15 days after reimplantation. The reason why this study can be justified is to identify the mechanisms involved in cell repair after tooth replantation in osteoporotic animals by means of immunohistochemistry reaction, which is a methodological tool that can aid in understanding and justification of the facts disclosed. (AU)

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