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Toll-like receptors and NOD-like receptors in pregnancy-associated malaria pathogenesis: effects and mechanisms

Grant number: 11/17880-8
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): January 01, 2012
Effective date (End): June 30, 2013
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Cláudio Romero Farias Marinho
Grantee:Renato Barboza
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:09/53889-0 - Study of the immunopathological mechanisms involved in pregnancy-associated malaria, AP.JP


Malaria is a serious parasitic disease that affects about 500 million people annually. In endemic regions, placental malaria (PM) is a major cause of maternal and infant mortality. The severity of the disease may be explained by the fact that placenta is an appropriated environment to the development of subpopulations of parasites, and by the immune profile developed by pregnant women infected with plasmodium. The Toll like receptors (TLR) and NOD-type (NLR) have been correlated with the recognition of structures present in the plasmodium, and with the mediation of inflammatory response against the parasite that is responsible for generating many of deleterious effects of infection. Although in recent years many studies have defined the clinical manifestations of malaria during pregnancy, the cellular and molecular mechanisms associated with the immune response are not understood. The aim of this project is to study the effects and immunological mechanisms involved in PM related to the TLR and NLR. For this purpose, we will use an experimental model that mimics the situation observed in areas of stable transmission, which was developed by our group. The understandings of these processes are important for the development of prophylactic and therapeutic strategies for treatment of malaria during pregnancy. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARBOZA, RENATO; REIS, ARAMYS SILVA; DA SILVA, LEANDRO GUSTAVO; HASENKAMP, LUTERO; BENEVIDES PEREIRA, KEITTY RAQUEL; SARAIVA CAMARA, NIELS OLSEN; MARANHAO COSTA, FABIO TRINDADE; D'IMPERIO LIMA, MARIA REGINA; ALVAREZ, JOSE MARIA; BOSCARDIN, SILVIA BEATRIZ; et al. MyD88 Signaling Is Directly Involved in the Development of Murine Placental Malaria. Infection and Immunity, v. 82, n. 2, p. 830-838, . (09/53256-7, 11/17880-8, 12/02270-2, 09/53889-0)
BARBOZA, RENATO; SARAIVA CAMARA, NIELS OLSEN; GOMES, ELIANE; SA-NUNES, ANDERSON; FLORSHEIM, ESTHER; MIROTTI, LUCIANA; LABRADA, ALEXIS; ALCANTARA-NEVES, NEUZA MARIA; RUSSO, MOMTCHILO. Endotoxin Exposure during Sensitization to Blomia tropicalis Allergens Shifts TH2 Immunity Towards a TH17-Mediated Airway Neutrophilic Inflammation: Role of TLR4 and TLR2. PLoS One, v. 8, n. 6, . (11/17880-8)
REIS, ARAMYS S.; BARBOZA, RENATO; MURILLO, OSCAR; BARATEIRO, ANDRE; PEIXOTO, ERIKA P. M.; LIMA, FLAVIA A.; GOMES, VINICIUS M.; DOMBROWSKI, JAMILLE G.; LEAL, VINICIUS N. C.; ARAUJO, FRANCIELE; et al. Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes. SCIENCE ADVANCES, v. 6, n. 10, . (14/09964-5, 15/23395-6, 14/20451-0, 17/03939-7, 11/19048-8, 17/05782-8, 13/16417-8, 16/07030-0, 12/16525-2, 12/04755-3, 15/50650-7, 18/20468-0, 13/00981-1, 11/17880-8, 15/06106-0)
BARBOZA, RENATO; LIMA, FLAVIA AFONSO; REIS, ARAMYS SILVA; MURILLO, OSCAR JAVIER; MACHADO PEIXOTO, ERIKA PAULA; BANDEIRA, CARLA LETICIA; FOTORAN, WESLEY LUZETTI; SARDINHA, LUIS ROBERTO; WUNDERLICH, GERHARD; BEVILACQUA, ESTELA; et al. TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria. SCIENTIFIC REPORTS, v. 7, . (12/16525-2, 11/17880-8, 14/20451-0, 14/09964-5, 15/06106-0, 13/00981-1, 11/19048-8, 13/16417-8, 09/53889-0)
BARBOZA, RENATO; HASENKAMP, LUTERO; BARATEIRO, ANDRE; MURILLO, OSCAR; MACHADO PEIXOTO, ERIKA PAULA; LIMA, FLAVIA AFONSO; REIS, ARAMYS SILVA; GONCALVES, LIGIA ANTUNES; EPIPHANIO, SABRINA; MARINHO, CLAUDIO R. F.. Fetal-Derived MyD88 Signaling Contributes to Poor Pregnancy Outcomes During Gestational Malaria. FRONTIERS IN MICROBIOLOGY, v. 10, . (11/17880-8, 15/10892-1, 09/53256-7, 12/14715-9, 16/07030-0, 15/06106-0, 17/03939-7, 11/19048-8, 13/16417-8, 09/53889-0)

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