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Study of sleep and the pattern of sleep-wake cycle as possible predictors of developing psychosis in bipolar disorder and individuals with mental states at risk

Grant number: 11/10925-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2011
Effective date (End): November 30, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Sergio Tufik
Grantee:Juliana Pedroso Moraes Vilela de Castro
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention, AP.TEM


Although recent evidences suggest being possible identify early psychosis and bipolar disorder based from clinical, the current knowledge lacks efficient mechanisms to predict this disease. Behavioral data support the hypothesis that psychosis could be associated to sleep disturbances. In addition, sleep changes list with emotional responses to different events. It is possible that sleep and sleep-wake disturbances are present in prodromal stages of these mental diseases and possible be useful as predictors of conversion to them in at-risk populations. Our aim is to verify if there is some sleep and sleep-wake patterns alteration in individuals in ultra-high risk (UHR) for psychosis and bipolar disorder. The volunteers are submitted to in-lab full-night polysomnographies to analyze their sleep patterns, use an actigraphy to record their sleep circadian rhythm pattern (15 days), and also fulfill questionnaire of sleep and circadian rhythms.