Vogt-Koyanagi-Harada disease: parameters for effective treatment on acute phase and long-standing disease

• Grant number: 11/19194-4
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: December 01, 2011
• End date: July 31, 2013
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Joyce Hisae Yamamoto Takiuti
• Grantee: Viviane Mayumi Sakata
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disease that targets melanocyte related proteins of genetically susceptible individuals. Its clinical course is subdivided into four phases: prodromal (flu-like symptoms), uveitis, convalescent and chronic. Pigmentary alterations of the choroid and skin may be observed in the course of either convalescent and/or chronic phases. Some authors have drawn attention to the progression of these alterations in cases with little or none overt inflammation and have correlated this phenomenon with disease severity. Da Silva et al. conducted a prospective transversal study (supported by FAPESP grant 07/57.155-5 and scholarship 07/57.154-9) in which 30 to 60% of patients had poor outcome. Thus, questions related to the efficacy of the initial treatment and also related to the effetiveness of disease and treatment monitorization in the late stage arise. The present longitudinal and prospective study, with a minimum one-year follow-up, aims to: 1. a global analysis of patients in the acute phase treated with methilprednisolone pulsetherapy; 2. a global analysis of late stage patients; and; 3. evaluate the impact of systemic treatment when disease worsening is detected by electrorretinographic exams. Global analysis is defined as disease activity evaluated by clinical exams and indocyanine green angiography, structure (fundoscopy and spectral optical coherence tomography) and function (electrorretinography and fundus autofluorescence). The results expected from this study are: understand the relevance of the analysis of each parameter (clinic, structure, function) in the acute phase and late stage and to monitor disease progression and treatment outcome. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LAVEZZO, MARCELO MENDES; SAKATA, VIVIANE MAYUMI; MORITA, CELSO; CASO RODRIGUEZ, EVER ERNESTO; ABDALLAH, SMAIRAH FRUTUOSO; DA SILVA, FELIPE T. G.; HIRATA, CARLOS EDUARDO; YAMAMOTO, JOYCE HISAE. Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. ORPHANET JOURNAL OF RARE DISEASES, v. 11, MAR 24 2016. (11/50936-7, 11/19194-4)

SAKATA, VIVIANE M.; DA SILVA, FELIPE T.; HIRATA, CARLOS E.; TAKAHASHI, WALTER Y.; COSTA, ROGERIO A.; YAMAMOTO, JOYCE H.. Choroidal bulging in patients with Vogt-Koyanagi-Harada disease in the non-acute uveitic stage. JOURNAL OF OPHTHALMIC INFLAMMATION AND INFECTION, v. 4, p. 5-pg., 2014-01-01. (11/50936-7, 11/19194-4)

LAVEZZO, MARCELO MENDES; SAKATA, VIVIANE MAYUMI; CASO RODRIGUEZ, EVER ERNESTO; ABDALLAH, SMAIRAH FRUTUOSO; MORITA, CELSO; MACHADO, CLEIDE GUIMARAES; GOLDBAUM, MAURO; GIANOTTI PIMENTEL, SERGIO LUIS; OYAMADA, MARIA KIYOKO; HIRATA, CARLOS EDUARDO; et al. Is there any choroidal inflammation in the non-acute stage of Vogt-Koyanagi-Harada disease (VKHD)?. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 57, n. 12, p. 3-pg., 2016-09-01. (11/19194-4, 11/50936-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SAKATA, Viviane Mayumi. Integrated analysis of clinical, structural and functional parameters in the acute and non-acute phases of Vogt-Koyanagi-Harada disease: a prospective study. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.