Today breast cancer is a cancer that affects more women in the world with high mortality rate mainly related to late diagnosis and tumor metastasis. The metastatic cells have a skeletal little structure and a low anchor that allows the invasiveness of cells. The migration and anchorage, which occur through rearrangements of cytoskeleton the actin of the cell are processes regulated by external signals and intracellular effectors, including protein Rho-associated kinase (ROCK). Thus, the expression of ROCK is negatively correlated to the survival of patients with breast cancer, and increased in late-stage tumors and metastases. Some studies have shown that melatonin, a hormone secreted by the pineal gland, presents oncostatics effects and anti-metastatic. The objective of this study is to evaluate the effects of treatment with melatonin on ROCK-mediated metastasis in breast cancer. The protein expression of ROCK will be analyzed through the technique of immunocytochemistry. Informations obtained in this study can contribute to evidence for future therapeutic applications of melatonin in cancer patients, reducing tumor growth and metastasis formation.
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